{"id":"W3171592362","doi":"10.1101/2021.06.01.446617","title":"Efficacy of epetraborole against <i>Mycobacterium abscessus</i> is increased with norvaline","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Mycobacterium research and diagnosis","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre","funders":"Argonne National Laboratory; Office of Science; Natural Sciences and Engineering Research Council of Canada; Cystic Fibrosis Canada; U.S. Department of Energy; McGill University; Canadian Institutes of Health Research; McGill University Health Centre; University of Saskatchewan; Canadian Light Source","keywords":"Norvaline; Mycobacterium abscessus; Mutant; Amino acid; Mycobacterium tuberculosis; Aminoacylation; In vitro; Chemistry; Biology; Transfer RNA; Biochemistry; Molecular biology; Mycobacterium; Leucine; Medicine; Genetics; Tuberculosis; RNA; Bacteria","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001666077,0.0002538733,0.000308207,0.0001210414,0.0000667416,0.0002338021,0.000217738,0.0002477553,0.001215355],"category_scores_gemma":[0.000237536,0.0000863723,0.0001338039,0.00008761171,0.0001613488,0.0001591497,0.0001577714,0.0004726064,0.0003351497],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001196659,"about_ca_system_score_gemma":0.0001018586,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002326675,"about_ca_topic_score_gemma":0.0002375981,"domain_scores_codex":[0.9998384,0.00005245569,0.0000149884,0.00002189211,0.00003470172,0.00003754814],"domain_scores_gemma":[0.999797,0.00006219447,0.00004120632,0.00001985204,0.00002593133,0.00005371053],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001049672,0.00009213058,0.0001619956,0.00004622735,0.000007448694,0.00003630306,0.00001140018,0.0000805692,0.9959442,0.00003121004,0.00008163157,0.002457222],"study_design_scores_gemma":[0.00002033516,0.001332992,0.001177558,0.00000487622,0.00000903331,0.0000940441,0.000006843024,0.0002660724,0.9962096,0.000009125256,0.0008671907,0.000002435787],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949507,0.001770818,0.0009034926,0.0001148369,0.00004842051,0.0000235518,0.0002568536,0.000113525,0.00181791],"genre_scores_gemma":[0.9968438,0.0003818238,0.0009493425,0.00004449016,0.00001876219,0.00001314734,0.0003618291,0.00002053769,0.001366267],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001215355,"threshold_uncertainty_score":0.004065812,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01298473073810945,"score_gpt":0.2398020145610134,"score_spread":0.2268172838229039,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}