{"id":"W3171612082","doi":"10.1093/ndt/gfab080.006","title":"MO034A SUBGROUP ANALYSIS OF FEMALE PATIENTS IN A PHASE 3 OPEN-LABEL STUDY TO ASSESS THE SAFETY AND EFFICACY OF PEGUNIGALSIDASE ALFA IN PATIENTS WITH FABRY DISEASE PREVIOUSLY TREATED WITH AGALSIDASE ALFA","year":2021,"lang":"en","type":"article","venue":"Nephrology Dialysis Transplantation","topic":"Lysosomal Storage Disorders Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"","keywords":"Medicine; Renal function; Fabry disease; Internal medicine; Enzyme replacement therapy; Pharmacokinetics; Subgroup analysis; Urology; Surgery; Disease; Confidence interval","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002400163,0.0007461993,0.002186037,0.0003787464,0.0003624565,0.0007790479,0.0003974061,0.0007870848,0.002498593],"category_scores_gemma":[0.001657542,0.0002367892,0.004809333,0.0003847791,0.0002398451,0.0003575496,0.0003859265,0.0007548263,0.0003661888],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004775806,"about_ca_system_score_gemma":0.0006830361,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006905092,"about_ca_topic_score_gemma":0.001765009,"domain_scores_codex":[0.9988558,0.0005355029,0.0001412826,0.0002152688,0.0001245607,0.0001274873],"domain_scores_gemma":[0.9991782,0.0002017812,0.0002458978,0.0001249941,0.0000952776,0.0001538349],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.7118731,0.002582027,0.1781735,0.001005894,0.03066147,0.0005675397,0.0001967883,0.0007816455,0.02078025,0.0002180411,0.003677168,0.04948265],"study_design_scores_gemma":[0.2003927,0.1048922,0.6298271,0.0002573684,0.04083684,0.001520419,0.0004402525,0.004150114,0.004573508,0.0007939539,0.01216634,0.0001491825],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9908637,0.004690708,0.0006614989,0.0002865622,0.0001437888,0.0006978463,0.001593705,0.0000327733,0.00102937],"genre_scores_gemma":[0.9943401,0.0005729398,0.0006316851,0.0006314586,0.0001293584,0.0007888025,0.002297673,0.00001500124,0.0005930078],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002498593,"threshold_uncertainty_score":0.01269341,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02472042269987504,"score_gpt":0.3224335194310765,"score_spread":0.2977130967312014,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}