{"id":"W3171665778","doi":"10.1136/jitc-2020-002140","title":"Immunotherapy using IgE or CAR T cells for cancers expressing the tumor antigen SLC3A2","year":2021,"lang":"en","type":"article","venue":"Journal for ImmunoTherapy of Cancer","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"Medical Research Council; Breast Cancer Now; Academy of Medical Sciences; Cancer Research UK","keywords":"Immunotherapy; Medicine; Antigen; Immunoglobulin E; Cancer immunotherapy; Immunology; Cancer research; Immune system; Antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001030561,0.0003485378,0.000847585,0.0001829946,0.0006722439,0.0001703871,0.0004226234,0.0001327893,0.003939866],"category_scores_gemma":[0.00006541557,0.0002282264,0.0008627032,0.0004145415,0.00024823,0.0002026545,0.00003057571,0.0005063626,0.000001003113],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009393544,"about_ca_system_score_gemma":0.003383218,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004385335,"about_ca_topic_score_gemma":0.0001055279,"domain_scores_codex":[0.9971441,0.000137363,0.0008737571,0.0003588254,0.0007173494,0.0007685781],"domain_scores_gemma":[0.9970537,0.0004507852,0.000595892,0.0006339214,0.001123157,0.0001425441],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.009939585,0.0001005138,0.000377091,0.0001525827,0.001274745,0.00002688682,0.001506791,0.0005130871,0.9078522,0.00001341671,0.00237684,0.07586629],"study_design_scores_gemma":[0.007427081,0.0005788206,0.0002878859,0.0005057537,0.00009439402,0.0002822567,0.0008889338,0.000963047,0.6212004,0.0001340451,0.3674049,0.0002324837],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9126689,0.07230034,0.007454014,0.001953923,0.00289958,0.002293276,0.0001883997,0.00003443174,0.0002071211],"genre_scores_gemma":[0.5773563,0.2023058,0.07370142,0.01867511,0.01448336,0.00192359,0.00007822077,0.001974198,0.1095019],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3650281,"threshold_uncertainty_score":0.9969707,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0655862087547177,"score_gpt":0.4044719527983389,"score_spread":0.3388857440436212,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}