{"id":"W3171679244","doi":"10.1158/1078-0432.ccr-21-0748","title":"Relevance of Platinum-free Interval and <i>BRCA</i> Reversion Mutations for Veliparib Monotherapy after Progression on Carboplatin/Paclitaxel for g <i>BRCA</i> Advanced Breast Cancer (BROCADE3 Crossover)","year":2021,"lang":"en","type":"letter","venue":"Clinical Cancer Research","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"AbbVie","keywords":"Carboplatin; Veliparib; Medicine; Paclitaxel; BRCA mutation; Oncology; Breast cancer; Internal medicine; Cancer; Chemotherapy; Cisplatin; Genetics; Biology; DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001128721,0.0002749966,0.0006646035,0.0001523292,0.0001947459,0.0007033264,0.0002798172,0.0005118357,0.001266431],"category_scores_gemma":[0.0009926751,0.0001739364,0.0007226666,0.0001791637,0.000373547,0.0003053821,0.0001593603,0.001109553,0.0001402831],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005156187,"about_ca_system_score_gemma":0.0004165997,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00044204,"about_ca_topic_score_gemma":0.0009957971,"domain_scores_codex":[0.9996191,0.0001784752,0.00003281776,0.00008292808,0.00003135058,0.0000553507],"domain_scores_gemma":[0.999249,0.0002305036,0.0002582048,0.00006484649,0.00003170569,0.000165664],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.8250059,0.006463353,0.03922214,0.0003593665,0.001209805,0.0002034841,0.0001986792,0.001471083,0.04425878,0.0001642135,0.0007713344,0.08067182],"study_design_scores_gemma":[0.2804289,0.4941117,0.1968751,0.0001038819,0.002312079,0.001033089,0.0001307023,0.002682343,0.01918992,0.0003126643,0.002759525,0.00006010451],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"commentary","genre_scores_codex":[0.9987962,0.0006319711,0.00006829149,0.00004806267,0.00001272978,0.00006917858,0.00007486753,0.000007276759,0.0002913991],"genre_scores_gemma":[0.999586,0.000100411,0.00007567277,0.00004410915,0.00001562021,0.00002144812,0.00009372419,0.00000182451,0.0000610731],"genre_candidate":"commentary","genre_consensus":null,"teacher_disagreement_score":0.001266431,"threshold_uncertainty_score":0.005969286,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1451204946697747,"score_gpt":0.5106776394598908,"score_spread":0.365557144790116,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}