{"id":"W3171699140","doi":"10.1021/acs.jmedchem.1c00420","title":"Development of HDAC Inhibitors Exhibiting Therapeutic Potential in T-Cell Prolymphocytic Leukemia","year":2021,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"H2020 European Research Council; Canada Research Chairs; Ontario Ministry of Research, Innovation and Science; Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; Syöpäsäätiö; Academy of Finland; Horizon 2020 Framework Programme; Natural Sciences and Engineering Research Council of Canada; Syöpäjärjestöt; Austrian Science Fund; Canadian Cancer Society; Leukemia and Lymphoma Society of Canada","keywords":"Prolymphocytic leukemia; Cancer research; Chemistry; HDAC6; Romidepsin; Bendamustine; Combination therapy; Bortezomib; Leukemia; Epigenetics; Potency; Pharmacology; Histone deacetylase; Medicine; Immunology; Histone; Multiple myeloma; In vitro; Chronic lymphocytic leukemia; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007100701,0.0001646524,0.0003209939,0.00006858677,0.00004397967,0.00001033483,0.000227563,0.0001997695,0.00006357998],"category_scores_gemma":[0.0002221972,0.0001530655,0.0001418549,0.0001915863,0.0001113468,0.000006694564,0.0001054175,0.0003961515,0.000002028041],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003512728,"about_ca_system_score_gemma":0.003518952,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004469921,"about_ca_topic_score_gemma":0.000005609842,"domain_scores_codex":[0.9978833,0.00006318142,0.0008768385,0.0002222874,0.0006634316,0.000291005],"domain_scores_gemma":[0.9988253,0.00002260541,0.0004170412,0.0002032094,0.0003726733,0.0001591623],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001856681,0.000132573,0.0002947667,0.0002663369,0.00004273276,0.0003397011,0.0002339217,0.00009397031,0.9936768,3.198362e-7,0.0003745098,0.004358741],"study_design_scores_gemma":[0.001957607,0.00008976753,0.0002014294,0.0003154786,0.00002175639,0.0005896713,0.0009842389,0.00003676001,0.9927928,0.000005974247,0.002869183,0.0001352688],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937954,0.004649981,0.000237876,0.00007379985,0.0001344912,0.00005264663,0.000001496494,0.000002112217,0.001052198],"genre_scores_gemma":[0.9973127,0.0001338009,0.001539072,0.0000460069,0.0005658517,0.000003085321,0.00001199916,0.00002249324,0.0003649454],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00451618,"threshold_uncertainty_score":0.6242469,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009695318014349048,"score_gpt":0.2603993099789439,"score_spread":0.2507039919645949,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}