{"id":"W3171699140","doi":"10.1021/acs.jmedchem.1c00420","title":"Development of HDAC Inhibitors Exhibiting Therapeutic Potential in T-Cell Prolymphocytic Leukemia","year":2021,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"H2020 European Research Council; Canada Research Chairs; Ontario Ministry of Research, Innovation and Science; Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; Syöpäsäätiö; Academy of Finland; Horizon 2020 Framework Programme; Natural Sciences and Engineering Research Council of Canada; Syöpäjärjestöt; Austrian Science Fund; Canadian Cancer Society; Leukemia and Lymphoma Society of Canada","keywords":"Prolymphocytic leukemia; Cancer research; Chemistry; HDAC6; Romidepsin; Bendamustine; Combination therapy; Bortezomib; Leukemia; Epigenetics; Potency; Pharmacology; Histone deacetylase; Medicine; Immunology; Histone; Multiple myeloma; In vitro; Chronic lymphocytic leukemia; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001334325,0.0003431493,0.0002458617,0.0002277363,0.0001161421,0.0002824054,0.0001892345,0.0001655721,0.001015694],"category_scores_gemma":[0.00006582113,0.0001218323,0.0002097053,0.0002010162,0.0001040628,0.0001505584,0.0001191967,0.000399464,0.0003592733],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002820464,"about_ca_system_score_gemma":0.0002409751,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005549679,"about_ca_topic_score_gemma":0.001734263,"domain_scores_codex":[0.999954,0.000005603787,0.000003761889,0.00001116853,0.000008713101,0.00001670754],"domain_scores_gemma":[0.9999775,0.000003060114,0.00000602117,0.000002866714,0.000003272766,0.000007302574],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000450034,0.0001797335,0.0005000015,0.0001079184,0.00001809048,0.0001177238,0.00001614962,0.0005313195,0.9735329,0.0002611251,0.0002594043,0.02402556],"study_design_scores_gemma":[0.0003462071,0.003674131,0.004382143,0.0000182967,0.0001048661,0.0009390201,0.00002389341,0.001955247,0.9751419,0.0001113984,0.01329034,0.0000125741],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9692972,0.01538004,0.006980799,0.0002765054,0.00008321412,0.0002616904,0.001152944,0.0002668849,0.006300767],"genre_scores_gemma":[0.9883628,0.006006743,0.003171118,0.00007753753,0.00001478646,0.00006290508,0.0007424765,0.00001549018,0.001546129],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001015694,"threshold_uncertainty_score":0.003397822,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009695318014349048,"score_gpt":0.2603993099789439,"score_spread":0.2507039919645949,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}