{"id":"W3171699248","doi":"10.21203/rs.3.rs-561133/v1","title":"Season of Birth and Vulnerability to the Pathology of Alzheimer’s Disease: an in Vivo Positron Emission Tomography Study","year":2021,"lang":"en","type":"preprint","venue":"Research Square","topic":"Health, Environment, Cognitive Aging","field":"Environmental Science","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Institutes of Health; Genentech; IXICO; H. Lundbeck A/S; Servier; Eisai; Northern California Institute for Research and Education; Pfizer; Biogen; BioClinica; F. Hoffmann-La Roche; University of Southern California; Eli Lilly and Company; U.S. Department of Defense; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; National Center for Geriatrics and Gerontology; Novartis Pharmaceuticals Corporation; Bristol-Myers Squibb; Alzheimer's Association; Japan Society for the Promotion of Science; Foundation for the National Institutes of Health","keywords":"Standardized uptake value; Dementia; Positron emission tomography; Neuroimaging; Medicine; Disease; Vulnerability (computing); Alzheimer's disease; Internal medicine; Psychology; Nuclear medicine; Psychiatry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006181814,0.0002259335,0.000420399,0.000230562,0.000172632,0.00003383354,0.0005076177,0.0001455254,0.0004388419],"category_scores_gemma":[0.0005766366,0.0001802764,0.00008536074,0.0006670187,0.0005240517,0.0001113157,0.002919286,0.001094597,0.000004466828],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002073644,"about_ca_system_score_gemma":0.00011999,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002759087,"about_ca_topic_score_gemma":0.00262034,"domain_scores_codex":[0.991862,0.004559571,0.0004638918,0.001225367,0.001330174,0.0005589994],"domain_scores_gemma":[0.9976575,0.0003513072,0.0001291041,0.001342991,0.00005569921,0.0004633591],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001395942,0.001201594,0.9759896,0.0002898443,0.00001974754,0.00006340436,0.005572997,0.0006267588,0.008016206,0.000002307269,0.00004846586,0.008029458],"study_design_scores_gemma":[0.0002634269,0.0003942755,0.9915501,0.0002737044,0.00002218542,7.414401e-7,0.004109386,0.0003196535,0.002626047,0.0001374685,0.0001504817,0.000152527],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946391,0.001065047,0.0000440296,0.0007238212,0.00003446917,0.003097076,0.0001541033,0.00001316939,0.0002291559],"genre_scores_gemma":[0.999154,0.0002621998,0.0001803873,0.00003609602,0.00001979029,0.000278172,0.0000226484,0.00002500934,0.00002171681],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01556048,"threshold_uncertainty_score":0.735146,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0547765802505014,"score_gpt":0.3939340077722717,"score_spread":0.3391574275217702,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}