{"id":"W3171699248","doi":"10.21203/rs.3.rs-561133/v1","title":"Season of Birth and Vulnerability to the Pathology of Alzheimer’s Disease: an in Vivo Positron Emission Tomography Study","year":2021,"lang":"en","type":"preprint","venue":"Research Square","topic":"Health, Environment, Cognitive Aging","field":"Environmental Science","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Institutes of Health; Genentech; IXICO; H. Lundbeck A/S; Servier; Eisai; Northern California Institute for Research and Education; Pfizer; Biogen; BioClinica; F. Hoffmann-La Roche; University of Southern California; Eli Lilly and Company; U.S. Department of Defense; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; National Center for Geriatrics and Gerontology; Novartis Pharmaceuticals Corporation; Bristol-Myers Squibb; Alzheimer's Association; Japan Society for the Promotion of Science; Foundation for the National Institutes of Health","keywords":"Standardized uptake value; Dementia; Positron emission tomography; Neuroimaging; Medicine; Disease; Vulnerability (computing); Alzheimer's disease; Internal medicine; Psychology; Nuclear medicine; Psychiatry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007734085,0.0002090108,0.0002145804,0.0002939745,0.0002796657,0.0004768187,0.0001918594,0.0002056242,0.001086548],"category_scores_gemma":[0.002070738,0.0001653225,0.0003450474,0.000473892,0.0001525768,0.0002603884,0.000228547,0.000249733,0.0001367029],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001644201,"about_ca_system_score_gemma":0.0002033017,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007668908,"about_ca_topic_score_gemma":0.006387101,"domain_scores_codex":[0.9997831,0.00009157669,0.00001563047,0.00006394419,0.00001566962,0.00003012978],"domain_scores_gemma":[0.9989874,0.0003180181,0.0003322167,0.0001275022,0.00009911222,0.0001356943],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003437896,0.00003618646,0.9974554,0.000008699441,0.0001273838,0.0000657968,0.0001200332,0.00002827174,0.0005179672,0.00002583561,0.00005437467,0.001216354],"study_design_scores_gemma":[0.0000027002,0.00005213208,0.9994954,0.000002276445,0.00003156867,0.00005510811,0.00007664222,0.00007054096,0.00006648181,0.00001699862,0.0001288894,0.000001218328],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992933,0.0001649793,0.0001560382,0.0000215782,0.000009989344,0.000002476118,0.000203349,0.000001311803,0.0001468566],"genre_scores_gemma":[0.9993798,0.0001021853,0.000104496,0.0000122512,0.00001217987,0.000003457139,0.0002086743,0.000003416051,0.0001736278],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007668908,"threshold_uncertainty_score":0.01524854,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0547765802505014,"score_gpt":0.3939340077722717,"score_spread":0.3391574275217702,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}