{"id":"W3171737412","doi":"10.1111/febs.16061","title":"Matrix metalloproteinase‐2 mediates ribosomal RNA transcription by cleaving nucleolar histones","year":2021,"lang":"en","type":"article","venue":"FEBS Journal","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"Northern Alberta Institute of Technology; Alberta Cancer Foundation; University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Ribosome biogenesis; Nucleolus; Biology; Cell biology; RNA polymerase I; Transcription (linguistics); Molecular biology; RNA; Ribosome; Gene; Genetics; RNA-dependent RNA polymerase; Nucleus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001954599,0.0001199821,0.0001220849,0.00003004973,0.0002259693,0.00009211809,0.0001476613,0.000111692,0.0003506799],"category_scores_gemma":[0.00004692648,0.0001141484,0.0001491196,0.00007883742,0.00004314759,0.00001394336,0.00002382622,0.0001763464,0.00002419565],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003533025,"about_ca_system_score_gemma":0.000114708,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008927919,"about_ca_topic_score_gemma":0.000008421033,"domain_scores_codex":[0.9990633,0.00007925539,0.0002597849,0.0002128583,0.0001763807,0.0002084357],"domain_scores_gemma":[0.9994134,0.000003437688,0.0001161577,0.0001905152,0.0001605773,0.0001158722],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002927836,0.00005425521,0.0001932109,0.000007821194,0.00005598317,0.00001673165,0.00003970313,0.00002233748,0.9842462,0.00006853742,0.01092831,0.004337664],"study_design_scores_gemma":[0.0005037689,0.00008912535,0.001160614,0.00001638679,0.00004789939,0.0002946301,0.0001422721,0.00003349174,0.6598927,0.0001381993,0.3375015,0.0001793843],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9695071,0.02151855,0.006490798,0.00110591,0.0004843741,0.00006486462,0.00003968052,0.0000116167,0.0007771205],"genre_scores_gemma":[0.991468,0.002419447,0.001823198,0.0001747889,0.0006057753,0.00001072219,0.000127021,0.00002485759,0.00334624],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3265732,"threshold_uncertainty_score":0.4654839,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008664128657972241,"score_gpt":0.2498110397509719,"score_spread":0.2411469110929996,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}