{"id":"W3171875784","doi":"10.1101/2021.06.07.21258484","title":"A functionally distinct neutrophil landscape in severe COVID-19 reveals opportunities for adjunctive therapies","year":2021,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","field":"Immunology and Microbiology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Canadian Institutes of Health Research","keywords":"ARDS; Neutrophil extracellular traps; Immunology; Diffuse alveolar damage; Medicine; Effector; Pneumonia; Immune system; Immunotherapy; Lung; Inflammation; Acute respiratory distress; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002384821,0.0002598738,0.0004031228,0.0001246653,0.0001293524,0.0005327731,0.0001621305,0.0003375947,0.001499919],"category_scores_gemma":[0.0001125101,0.00006981835,0.000167289,0.00007205727,0.0002080501,0.0002041296,0.0003391669,0.0007177171,0.0003517409],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002304916,"about_ca_system_score_gemma":0.0001657988,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000107575,"about_ca_topic_score_gemma":0.0002062348,"domain_scores_codex":[0.9999173,0.00002144968,0.000005448587,0.00001477736,0.00001824725,0.00002276282],"domain_scores_gemma":[0.9999536,0.000005534422,0.0000107047,0.000005223809,0.00000732741,0.00001761901],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001126004,0.0001491898,0.003695291,0.0002289049,0.00001953249,0.0003779485,0.0000404242,0.0003665314,0.9684426,0.001235217,0.001120542,0.02319788],"study_design_scores_gemma":[0.0003669705,0.005013524,0.1081606,0.0002627566,0.0001123577,0.006085237,0.0005873064,0.007437214,0.7999111,0.004596458,0.06742933,0.00003726813],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9559445,0.02238447,0.01183478,0.002017403,0.0003647039,0.0001566592,0.0009640553,0.0002601201,0.006073412],"genre_scores_gemma":[0.9873151,0.004328238,0.0045828,0.0004601468,0.0001070293,0.00006291563,0.0007029421,0.00002198011,0.002418884],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001499919,"threshold_uncertainty_score":0.005017757,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07453492966193614,"score_gpt":0.2837142268710103,"score_spread":0.2091792972090741,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}