{"id":"W3171947585","doi":"10.1200/jco.2021.39.15_suppl.tps5600","title":"Trial in progress: A phase 1, multicenter, open-label, dose-exploration and dose-expansion study evaluating the safety, tolerability, pharmacokinetics, and efficacy of AMG650 in subjects with advanced solid tumors.","year":2021,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"","keywords":"Medicine; Tolerability; Endometrial cancer; Oncology; Internal medicine; Triple-negative breast cancer; Cancer; Serous fluid; Response Evaluation Criteria in Solid Tumors; Ovarian cancer; Breast cancer; Clinical trial; Phases of clinical research; Adverse effect","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002356732,0.002429781,0.002095973,0.0005946505,0.0005833886,0.001342772,0.001261518,0.00213512,0.007554302],"category_scores_gemma":[0.001299401,0.0006869265,0.001152638,0.0005953761,0.001226025,0.001436944,0.0004688614,0.00414408,0.001878761],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009312117,"about_ca_system_score_gemma":0.002085496,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006418423,"about_ca_topic_score_gemma":0.001442075,"domain_scores_codex":[0.9994053,0.0002922873,0.00002299383,0.0001089949,0.00006212327,0.0001083406],"domain_scores_gemma":[0.9990233,0.0001217802,0.0002587799,0.00008506573,0.00007663619,0.00043442],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7650642,0.07515329,0.005577666,0.001245012,0.001159165,0.0004571603,0.0005206108,0.003324002,0.05288171,0.0008920428,0.0105151,0.08320996],"study_design_scores_gemma":[0.62071,0.3634234,0.006014601,0.00005204498,0.0002756524,0.0003902097,0.00007086121,0.001309677,0.00260516,0.0004739683,0.004641458,0.00003298584],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9744453,0.002453587,0.002269739,0.001161842,0.0002300671,0.01062547,0.004229519,0.000478649,0.004105722],"genre_scores_gemma":[0.9572937,0.002789591,0.006343547,0.00313988,0.0003438281,0.01375291,0.008195212,0.0001522464,0.007988981],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007554302,"threshold_uncertainty_score":0.02527165,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1472701688662718,"score_gpt":0.5227100427634691,"score_spread":0.3754398738971974,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}