{"id":"W3171979649","doi":"10.1096/fasebj.24.1_supplement.lb442","title":"Insights into the pharmacologic inhibition of insulin receptor tyrosine kinase in cancer: avoiding severe metabolic toxicity","year":2010,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"Metabolism, Diabetes, and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Quebec - Clinical Research Organization in Cancer; McGill University","funders":"","keywords":"Hyperinsulinemia; Insulin; Insulin receptor; Endocrinology; Internal medicine; Glucose uptake; Protein kinase B; Tyrosine kinase; Receptor tyrosine kinase; Cancer; Medicine; Cancer research; Biology; Phosphorylation; Insulin resistance; Receptor; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003571148,0.0004397279,0.0003456245,0.0003109163,0.0001464032,0.0004100761,0.0003834595,0.0003589504,0.001245347],"category_scores_gemma":[0.0001275811,0.0001806496,0.0002448017,0.0001719248,0.0003000623,0.0004913845,0.000209123,0.0006986224,0.0002075777],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003359988,"about_ca_system_score_gemma":0.0004051172,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002863737,"about_ca_topic_score_gemma":0.0009548995,"domain_scores_codex":[0.9999074,0.0000250312,0.000009232054,0.00001184642,0.00002254173,0.0000240225],"domain_scores_gemma":[0.9999477,0.00001076947,0.00001652563,0.000006456734,0.000006721923,0.00001190941],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005783245,0.0003926541,0.0006938141,0.0004634669,0.00002635794,0.0003273429,0.00002877598,0.0009058682,0.9462804,0.00434001,0.0004842153,0.04547878],"study_design_scores_gemma":[0.000954072,0.01223317,0.0170954,0.000145397,0.0002181741,0.004185397,0.0001728724,0.004872561,0.8983786,0.004892114,0.05681132,0.00004098119],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.901502,0.05256369,0.02551804,0.005954425,0.0002259821,0.0002869971,0.0006759394,0.0002544832,0.01301835],"genre_scores_gemma":[0.9434586,0.04004124,0.01255275,0.0008500816,0.0001588535,0.00013582,0.0002680961,0.00002973155,0.002505022],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001245347,"threshold_uncertainty_score":0.004166126,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01306240666680326,"score_gpt":0.2661375614733529,"score_spread":0.2530751548065496,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}