{"id":"W3171994703","doi":"10.3389/fimmu.2021.669812","title":"Development of a Novel Multi-Epitope Vaccine Against Crimean-Congo Hemorrhagic Fever Virus: An Integrated Reverse Vaccinology, Vaccine Informatics and Biophysics Approach","year":2021,"lang":"en","type":"article","venue":"Frontiers in Immunology","topic":"vaccines and immunoinformatics approaches","field":"Biochemistry, Genetics and Molecular Biology","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Windsor","funders":"Guangxi University","keywords":"Epitope; Virology; Biology; Adjuvant; Reverse vaccinology; Antigen; Ebola virus; DNA vaccination; Immune system; Virus; Immunology; Immunization","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003050984,0.0004104537,0.0007035779,0.000246657,0.0001127643,0.00003304477,0.0004315635,0.0004724784,0.000007833076],"category_scores_gemma":[0.0001089957,0.0003908165,0.00009263115,0.0004007768,0.00007171459,0.00005565834,0.0004946967,0.0003692316,0.000002492],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006172405,"about_ca_system_score_gemma":0.0003097388,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003489885,"about_ca_topic_score_gemma":0.00005610291,"domain_scores_codex":[0.997803,0.00008368526,0.001116222,0.0003934464,0.0001065903,0.0004970077],"domain_scores_gemma":[0.9985198,0.00001064392,0.0003934823,0.0007400207,0.0002576117,0.00007845341],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000678572,0.002119333,0.007105031,0.0003926427,0.001004035,0.000008885419,0.004646973,0.0006425478,0.900882,0.000125427,0.001767299,0.08062726],"study_design_scores_gemma":[0.0279387,0.001046133,0.03263328,0.0002116633,0.0002146525,0.0004184206,0.05568101,0.09042846,0.7175791,0.00005690633,0.07129103,0.002500629],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"methods","genre_scores_codex":[0.9028162,0.00397194,0.09223978,0.00003297488,0.0004204989,0.0003277166,0.00003649038,0.00002241701,0.0001319397],"genre_scores_gemma":[0.23079,0.002589033,0.7641401,0.0003920877,0.00005116961,0.00005584099,0.001731143,0.00005733073,0.0001932886],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.6720262,"threshold_uncertainty_score":0.9998544,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01697378962945471,"score_gpt":0.2314436406631079,"score_spread":0.2144698510336532,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}