{"id":"W3172015457","doi":"10.1096/fasebj.2021.35.s1.04009","title":"The Mechanism of Quorum Sensing Inhibition in <i>Streptococcus pyogenes</i> by the Phage Protein Paratox","year":2021,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"Streptococcal Infections and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Prophage; Quorum sensing; Streptococcus pyogenes; Biology; Gene; Genetics; Cell biology; Bacteriophage; Chemistry; Staphylococcus aureus; Bacteria; Virulence; Escherichia coli","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002861851,0.0004448638,0.0003302588,0.0001839802,0.0003622508,0.0005061188,0.0004659223,0.0006280545,0.00120317],"category_scores_gemma":[0.0001692604,0.0002345738,0.0003543819,0.00008304881,0.0006208405,0.0005588756,0.0003512579,0.0004908672,0.00039641],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007486884,"about_ca_system_score_gemma":0.0003110692,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005058964,"about_ca_topic_score_gemma":0.0003416797,"domain_scores_codex":[0.9998261,0.00004055751,0.000009417748,0.00002725682,0.00005090954,0.00004581721],"domain_scores_gemma":[0.999909,0.00002408138,0.00002691413,0.000009325985,0.00001303674,0.00001760617],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000211295,0.00009496079,0.000727466,0.000221714,0.00001849835,0.0004336812,0.00008071624,0.0007396951,0.9881992,0.00521018,0.0002885357,0.003773995],"study_design_scores_gemma":[0.00007220241,0.0007298294,0.009261178,0.00003092578,0.00002484847,0.001043598,0.0001214342,0.01134659,0.9700788,0.001470335,0.005795267,0.00002501124],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9658772,0.01183069,0.01245745,0.001372402,0.0001273077,0.00009158198,0.0001438445,0.0002183169,0.007881138],"genre_scores_gemma":[0.9944722,0.001674879,0.001397285,0.0001540871,0.00002026799,0.00003214654,0.00006545684,0.000007673878,0.002175851],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00120317,"threshold_uncertainty_score":0.005432189,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01531931176289205,"score_gpt":0.2631609844338648,"score_spread":0.2478416726709728,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}