{"id":"W3172018226","doi":"10.2139/ssrn.3854707","title":"Optogenetic-Mediated Spatiotemporal Control of α-Synuclein Aggregation Mimics Lewy Body Formation and Triggers Neurodegeneration","year":2021,"lang":"en","type":"article","venue":"SSRN Electronic Journal","topic":"Photoreceptor and optogenetics research","field":"Neuroscience","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre hospitalier de l'Université Laval; University of Victoria; McGill University; Montreal Neurological Institute and Hospital; Université Laval","funders":"","keywords":"Optogenetics; Neurodegeneration; Neuroscience; Lewy body; Parkinson's disease; Medicine; Biology; Pathology; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001625695,0.000291372,0.0002410302,0.0001592805,0.0001686749,0.0004036297,0.0002876156,0.0004338991,0.001066506],"category_scores_gemma":[0.0001288426,0.0001524331,0.0002521692,0.0001515498,0.0003230685,0.0002233976,0.0002357246,0.0005933608,0.0003114503],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004206903,"about_ca_system_score_gemma":0.0002518145,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005812528,"about_ca_topic_score_gemma":0.001163897,"domain_scores_codex":[0.999864,0.00001460957,0.0000144948,0.00003443922,0.00003750019,0.00003488275],"domain_scores_gemma":[0.9998925,0.00002608502,0.00004286055,0.00001511784,0.000006421682,0.00001691178],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007530993,0.00002050179,0.00004191745,0.00001200736,0.000002903361,0.00006100063,0.000009005484,0.0001048417,0.9989895,0.0002342241,0.00003016958,0.0004186352],"study_design_scores_gemma":[0.00001312929,0.0000657267,0.0007597285,0.000002470384,0.000006051451,0.00007483282,0.00001603534,0.001084708,0.9973235,0.0000785632,0.0005722821,0.000003030119],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926581,0.0003497803,0.003912442,0.0001350048,0.00005609967,0.0000335918,0.000274895,0.0001347306,0.002445384],"genre_scores_gemma":[0.9956858,0.0003312858,0.0019929,0.00005065643,0.000005516964,0.0000232082,0.0001258895,0.00003698502,0.00174774],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001066506,"threshold_uncertainty_score":0.003567815,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01654842517215302,"score_gpt":0.260714879997205,"score_spread":0.244166454825052,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}