{"id":"W3172021204","doi":"10.1093/jncics/pkab056","title":"Association Between Smoking and Molecular Subtypes of Colorectal Cancer","year":2021,"lang":"en","type":"article","venue":"JNCI Cancer Spectrum","topic":"Colorectal Cancer Screening and Detection","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Memorial University of Newfoundland; Lunenfeld-Tanenbaum Research Institute; University of Toronto; Mount Sinai Hospital","funders":"National Cancer Institute; National Heart, Lung, and Blood Institute; Instituto de Salud Carlos III; National Health and Medical Research Council; World Cancer Research Fund; Medicinska fakulteten, Umeå Universitet; Medical Research Council; Centers for Disease Control and Prevention; National Institutes of Health; Hellenic Health Foundation; Institut Gustave-Roussy; Cancer Council Victoria; Deutsche Krebshilfe; Associazione Italiana per la Ricerca sul Cancro; Ontario Ministry of Research and Innovation; Deutsches Krebsforschungszentrum; Ligue Contre le Cancer; Cancer Research Foundation in Northern Sweden; NordForsk; Vetenskapsrådet; Canadian Institutes of Health Research; Cancerfonden; European Commission; Umeå Universitet; Bundesministerium für Bildung und Forschung; Institut National de la Santé et de la Recherche Médicale; Mutuelle Générale de l'Education Nationale; Kempe Foundation; Harvard T.H. Chan School of Public Health; Génome Québec; Canadian Cancer Society Research Institute; McGill University; Pelotonia; Brigham and Women's Hospital; World Health Organization; Cancer Research UK; American Cancer Society; University of Pittsburgh; Johns Hopkins University; Centre International de Recherche sur le Cancer; U.S. Department of Health and Human Services","keywords":"Medicine; Internal medicine; Colorectal cancer; Microsatellite instability; KRAS; Quartile; Oncology; Bonferroni correction; Logistic regression; Cancer; Allele; Genetics; Microsatellite; Biology; Confidence interval; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001349411,0.0001155398,0.0003227838,0.00007118566,0.00005495605,0.00001765831,0.00003271702,0.0001232532,0.0002396455],"category_scores_gemma":[0.00008099545,0.0001181099,0.00008300455,0.0003539909,0.000027408,0.00005380794,0.00003977176,0.0002101792,0.000001181504],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005308219,"about_ca_system_score_gemma":0.0002991941,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002130951,"about_ca_topic_score_gemma":0.001479781,"domain_scores_codex":[0.9989521,0.00003499191,0.0002020935,0.0002638615,0.0003266032,0.0002203515],"domain_scores_gemma":[0.9994593,0.00005536311,0.0001546029,0.0001100289,0.0001349425,0.00008581689],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004407397,0.00002258746,0.9603303,0.00009941189,0.0004757312,0.00002540019,0.0002075558,0.00002151201,0.02715168,0.0000626326,0.0004361371,0.01072628],"study_design_scores_gemma":[0.0007146411,0.000318349,0.5479795,0.0001166403,0.000342181,0.00001102757,0.00004294393,0.0001014653,0.448443,0.0001553906,0.001670441,0.0001043407],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9888299,0.0052645,0.0001448838,0.003149633,0.0003828098,0.0001259567,0.00003436645,0.00005416377,0.002013833],"genre_scores_gemma":[0.9980411,0.0006248146,0.0001271236,0.0001757195,0.0003467017,0.00003721242,0.000009940512,0.00001986649,0.0006175244],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4212914,"threshold_uncertainty_score":0.4816381,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01222727541476481,"score_gpt":0.2792233342080559,"score_spread":0.2669960587932911,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}