{"id":"W3172021204","doi":"10.1093/jncics/pkab056","title":"Association Between Smoking and Molecular Subtypes of Colorectal Cancer","year":2021,"lang":"en","type":"article","venue":"JNCI Cancer Spectrum","topic":"Colorectal Cancer Screening and Detection","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Memorial University of Newfoundland; Lunenfeld-Tanenbaum Research Institute; University of Toronto; Mount Sinai Hospital","funders":"National Cancer Institute; National Heart, Lung, and Blood Institute; Instituto de Salud Carlos III; National Health and Medical Research Council; World Cancer Research Fund; Medicinska fakulteten, Umeå Universitet; Medical Research Council; Centers for Disease Control and Prevention; National Institutes of Health; Hellenic Health Foundation; Institut Gustave-Roussy; Cancer Council Victoria; Deutsche Krebshilfe; Associazione Italiana per la Ricerca sul Cancro; Ontario Ministry of Research and Innovation; Deutsches Krebsforschungszentrum; Ligue Contre le Cancer; Cancer Research Foundation in Northern Sweden; NordForsk; Vetenskapsrådet; Canadian Institutes of Health Research; Cancerfonden; European Commission; Umeå Universitet; Bundesministerium für Bildung und Forschung; Institut National de la Santé et de la Recherche Médicale; Mutuelle Générale de l'Education Nationale; Kempe Foundation; Harvard T.H. Chan School of Public Health; Génome Québec; Canadian Cancer Society Research Institute; McGill University; Pelotonia; Brigham and Women's Hospital; World Health Organization; Cancer Research UK; American Cancer Society; University of Pittsburgh; Johns Hopkins University; Centre International de Recherche sur le Cancer; U.S. Department of Health and Human Services","keywords":"Medicine; Internal medicine; Colorectal cancer; Microsatellite instability; KRAS; Quartile; Oncology; Bonferroni correction; Logistic regression; Cancer; Allele; Genetics; Microsatellite; Biology; Confidence interval; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006575878,0.0001934751,0.0002943029,0.0007657891,0.0002027641,0.0004575202,0.0003107835,0.0002933852,0.001920535],"category_scores_gemma":[0.001888077,0.0001651229,0.0004263428,0.001008212,0.0001711546,0.0002173815,0.0002853601,0.0003346868,0.0001399116],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001475693,"about_ca_system_score_gemma":0.0001799897,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002473729,"about_ca_topic_score_gemma":0.003291747,"domain_scores_codex":[0.9994472,0.0001588555,0.00007723465,0.0001543631,0.00009385704,0.0000684905],"domain_scores_gemma":[0.9976775,0.0005437902,0.001127074,0.0001755034,0.0002114745,0.0002646704],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001160628,0.000006531455,0.997931,0.00001958274,0.0001421535,0.00002897623,0.0000082899,0.00001983062,0.0003744084,0.00001489184,0.00003136459,0.001306759],"study_design_scores_gemma":[0.000002956773,0.00002636158,0.9993337,0.000007974949,0.00007107011,0.0001628282,0.00001503081,0.0001142487,0.00007590212,0.00003991934,0.000148321,0.000001621282],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958688,0.002644411,0.0002329682,0.00006693671,0.00001341641,0.000007912993,0.0005576909,0.000007147451,0.0006007125],"genre_scores_gemma":[0.9992955,0.000227612,0.0001073021,0.00001384483,0.0000163843,0.000004060654,0.0002022443,0.00000208305,0.0001309873],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002473729,"threshold_uncertainty_score":0.006424785,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01222727541476481,"score_gpt":0.2792233342080559,"score_spread":0.2669960587932911,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}