{"id":"W3172081492","doi":"10.1056/nejmoa2103695","title":"Sotorasib for Lung Cancers with <i>KRAS</i> p.G12C Mutation","year":2021,"lang":"en","type":"article","venue":"New England Journal of Medicine","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":1769,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"National Cancer Institute; Amgen","keywords":"KRAS; Medicine; Lung cancer; Mutation; Lung; Cancer research; Internal medicine; Oncology; Cancer; Biology; Genetics; Colorectal cancer; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005765571,0.0003238117,0.0005084356,0.0003207768,0.000134917,0.0003718355,0.000203544,0.0003498386,0.002586788],"category_scores_gemma":[0.0003916044,0.00007935894,0.0004962424,0.0002912501,0.0002261401,0.0002536824,0.0001501861,0.0006357439,0.0004897],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004046801,"about_ca_system_score_gemma":0.0006124213,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003640465,"about_ca_topic_score_gemma":0.002032435,"domain_scores_codex":[0.9998473,0.0000652955,0.00001344154,0.00002671068,0.00002916488,0.00001803303],"domain_scores_gemma":[0.9997923,0.00005009113,0.00007810463,0.000009252655,0.00002325525,0.00004708598],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.09763154,0.002908661,0.02331595,0.007262185,0.002021597,0.001020464,0.0001724109,0.002455253,0.1016839,0.001067225,0.01916306,0.7412978],"study_design_scores_gemma":[0.151779,0.2996728,0.2421288,0.003239049,0.006660998,0.01286571,0.0003804654,0.006644149,0.09816899,0.002782585,0.1755104,0.0001669578],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8947292,0.080557,0.001362586,0.003455207,0.0003910014,0.001615289,0.002566879,0.0002035725,0.01511925],"genre_scores_gemma":[0.9709071,0.02012276,0.001927723,0.001522617,0.0001991484,0.0005018151,0.001963993,0.00001969395,0.002835153],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002586788,"threshold_uncertainty_score":0.008653641,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01351052059467178,"score_gpt":0.330700063136702,"score_spread":0.3171895425420302,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}