{"id":"W3172108663","doi":"10.1096/fasebj.2021.35.s1.05082","title":"HCAR1 Nuclear Location Bias Drives Cancer Malignancy by Multiple Routes","year":2021,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier Universitaire Sainte-Justine; Université de Montréal","funders":"Canadian Institutes of Health Research","keywords":"Nuclear localization sequence; Interactome; G protein-coupled receptor; Biology; Cell biology; Nuclear transport; Cancer; Phosphorylation; Cancer cell; Cancer research; Nuclear protein; Cell; Chemistry; Signal transduction; Cell nucleus; Biochemistry; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001371856,0.0002650268,0.0002641318,0.0002148533,0.0003615193,0.0005954456,0.0002215427,0.0003826523,0.004098047],"category_scores_gemma":[0.000112884,0.0001955695,0.0004609808,0.0001846685,0.0003490382,0.000263649,0.0002979141,0.0009428401,0.001522811],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007040557,"about_ca_system_score_gemma":0.0002787768,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001080923,"about_ca_topic_score_gemma":0.001556507,"domain_scores_codex":[0.9996701,0.00003241308,0.00001881856,0.0001155652,0.00008402849,0.00007905491],"domain_scores_gemma":[0.9998093,0.00002500322,0.00005487009,0.00003041218,0.00003122509,0.00004924611],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004837056,0.00001501703,0.0005583991,0.00003393823,0.000006352453,0.00006610841,0.00001689154,0.00005036313,0.9980388,0.0002094183,0.0001622028,0.0007941324],"study_design_scores_gemma":[0.00001207891,0.0001483208,0.01728555,0.00001293093,0.00002841366,0.001018222,0.0001395653,0.001408844,0.9720026,0.0001480833,0.007785046,0.00001038243],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9822827,0.004214109,0.007056673,0.0006652569,0.0001053074,0.00003429462,0.001312306,0.0002726918,0.004056764],"genre_scores_gemma":[0.9891744,0.001120211,0.002411026,0.0002515351,0.00001997972,0.00003352087,0.001102977,0.00004903711,0.005837453],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004098047,"threshold_uncertainty_score":0.01370937,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01547245271944212,"score_gpt":0.2456922029989816,"score_spread":0.2302197502795394,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}