{"id":"W3172139422","doi":"10.1200/jco.2021.39.15_suppl.4002","title":"First-line (1L) nivolumab (NIVO) plus chemotherapy (chemo) versus chemo in advanced gastric cancer/gastroesophageal junction cancer/esophageal adenocarcinoma (GC/GEJC/EAC): Expanded efficacy and safety data from CheckMate 649.","year":2021,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Gastric Cancer Management and Outcomes","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"Bristol-Myers Squibb Canada","keywords":"Medicine; Nivolumab; Internal medicine; Randomized controlled trial; Ipilimumab; Cancer; Population; Oncology; Adverse effect; FOLFOX; Clinical endpoint; Gastroenterology; Oxaliplatin; Colorectal cancer; Immunotherapy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001388943,0.0006872598,0.001392271,0.0003121658,0.0002541326,0.0005687442,0.0006773465,0.0008188316,0.00374505],"category_scores_gemma":[0.001083752,0.0003338958,0.00122481,0.0002699562,0.0004909924,0.0005555893,0.0003028697,0.001667085,0.000414701],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001146471,"about_ca_system_score_gemma":0.0009385066,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007870503,"about_ca_topic_score_gemma":0.003396378,"domain_scores_codex":[0.9995449,0.0002602158,0.00002981985,0.00006929814,0.0000346044,0.00006122098],"domain_scores_gemma":[0.9992995,0.0001848402,0.0001815133,0.00004780618,0.00003030336,0.0002560176],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.9209226,0.01382159,0.002186512,0.0007148364,0.0009268605,0.00004368405,0.00006000591,0.000910772,0.005847027,0.00009324446,0.001052067,0.05342084],"study_design_scores_gemma":[0.5268841,0.4501472,0.01354023,0.0001034296,0.001883513,0.0001286707,0.00004602415,0.001477874,0.003661863,0.0002471398,0.001851507,0.0000283519],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937661,0.002622613,0.0002708368,0.0002105211,0.0001290918,0.001053524,0.0006352951,0.00005085262,0.00126125],"genre_scores_gemma":[0.9944687,0.001406404,0.0007249669,0.0004172083,0.0001246439,0.0009012572,0.0006310683,0.00001324357,0.001312421],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00374505,"threshold_uncertainty_score":0.01252842,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1266036482069207,"score_gpt":0.4363656036335343,"score_spread":0.3097619554266136,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}