{"id":"W3172164606","doi":"10.1128/mbio.00592-21","title":"A Dual-Specificity Inhibitor Targets Polyphosphate Kinase 1 and 2 Enzymes To Attenuate Virulence of Pseudomonas aeruginosa","year":2021,"lang":"en","type":"article","venue":"mBio","topic":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","field":"Medicine","cited_by":60,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Cystic Fibrosis Canada; Natural Sciences and Engineering Research Council of Canada; Government of Canada","keywords":"Pseudomonas aeruginosa; Biofilm; Virulence; Polyphosphate; Microbiology; Biology; Pyocyanin; Enzyme; Bacteria; Cell biology; Biochemistry; Quorum sensing; Gene; Genetics; Phosphate","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001584977,0.0006849908,0.000397856,0.0002906321,0.0001707855,0.0003578639,0.0003071407,0.0004513429,0.002376875],"category_scores_gemma":[0.0001100035,0.0001963466,0.0003326503,0.0001824609,0.0002827486,0.0002806406,0.0002056294,0.001102149,0.0004337305],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000351236,"about_ca_system_score_gemma":0.0003312777,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005329847,"about_ca_topic_score_gemma":0.001788875,"domain_scores_codex":[0.9997175,0.00002977376,0.00002696928,0.00007376833,0.00008340803,0.00006855085],"domain_scores_gemma":[0.999916,0.00001366877,0.00002299045,0.000009966232,0.000007268436,0.00003009418],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001824685,0.00007790954,0.00007910535,0.00005304337,0.00000716121,0.00003518688,0.000006451881,0.0000715963,0.9973559,0.0001221096,0.0001205939,0.001888396],"study_design_scores_gemma":[0.00003874019,0.0005262922,0.001206532,0.000005988732,0.0000131192,0.0002101457,0.00001127743,0.0006668669,0.9937105,0.00003833134,0.003565469,0.000006678607],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.959116,0.005918363,0.02230685,0.0006237703,0.0004426439,0.0003577698,0.002296042,0.0006290863,0.00830962],"genre_scores_gemma":[0.9746028,0.00216824,0.01265428,0.000193224,0.00003641358,0.0002285234,0.0009749986,0.00007598267,0.009065593],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002376875,"threshold_uncertainty_score":0.007951498,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01537689533659207,"score_gpt":0.2568773241288684,"score_spread":0.2415004287922763,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}