{"id":"W3172346058","doi":"10.1038/s41419-021-03904-4","title":"USP35, regulated by estrogen and AKT, promotes breast tumorigenesis by stabilizing and enhancing transcriptional activity of estrogen receptor α","year":2021,"lang":"en","type":"article","venue":"Cell Death and Disease","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Key Discipline of Zhejiang Province in Medical Technology; Hospital for Sick Children; Natural Science Foundation of Zhejiang Province; National Natural Science Foundation of China","keywords":"Fulvestrant; Estrogen receptor; Breast cancer; Tamoxifen; Cancer research; PI3K/AKT/mTOR pathway; PTEN; Estrogen receptor alpha; Protein kinase B; Estrogen; Carcinogenesis; Cancer; Biology; Internal medicine; Endocrinology; Signal transduction; Medicine; Cell biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001950343,0.0003334107,0.0002189327,0.0003681528,0.0002295021,0.0002397973,0.0001463948,0.0002141359,0.001316085],"category_scores_gemma":[0.0001692612,0.0001801214,0.0004361718,0.0002181468,0.0002356725,0.0001816594,0.0002424443,0.0003162376,0.0002328553],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004284236,"about_ca_system_score_gemma":0.0002405688,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006212155,"about_ca_topic_score_gemma":0.0007444747,"domain_scores_codex":[0.999858,0.00001787392,0.0000124245,0.00003492449,0.00004429714,0.00003241114],"domain_scores_gemma":[0.9999008,0.000009619743,0.00004416961,0.000008297357,0.00001555128,0.00002149479],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002471746,0.00003457395,0.001885152,0.0001222679,0.00002146109,0.000237473,0.00003264546,0.0001448118,0.9876116,0.0004827666,0.0003044582,0.008875726],"study_design_scores_gemma":[0.00007317617,0.0004268664,0.02471919,0.00001993971,0.00009662331,0.001749815,0.0000635328,0.001748063,0.9512932,0.000455257,0.01933478,0.00001955134],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9791926,0.0110631,0.005440448,0.000291252,0.00006172733,0.00004031672,0.0006180995,0.0002598456,0.00303253],"genre_scores_gemma":[0.9938685,0.002276479,0.001496229,0.00008300249,0.0000134552,0.00001487412,0.0004766023,0.00001655376,0.001754297],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001316085,"threshold_uncertainty_score":0.004402697,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006967777413555831,"score_gpt":0.2059299169743842,"score_spread":0.1989621395608284,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}