{"id":"W3172346058","doi":"10.1038/s41419-021-03904-4","title":"USP35, regulated by estrogen and AKT, promotes breast tumorigenesis by stabilizing and enhancing transcriptional activity of estrogen receptor α","year":2021,"lang":"en","type":"article","venue":"Cell Death and Disease","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Key Discipline of Zhejiang Province in Medical Technology; Hospital for Sick Children; Natural Science Foundation of Zhejiang Province; National Natural Science Foundation of China","keywords":"Fulvestrant; Estrogen receptor; Breast cancer; Tamoxifen; Cancer research; PI3K/AKT/mTOR pathway; PTEN; Estrogen receptor alpha; Protein kinase B; Estrogen; Carcinogenesis; Cancer; Biology; Internal medicine; Endocrinology; Signal transduction; Medicine; Cell biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000867226,0.0001575806,0.000155041,0.00001507994,0.00009712953,0.00003081867,0.00004135149,0.00007786331,0.00003427187],"category_scores_gemma":[0.00003942455,0.0001583201,0.0000502597,0.00004375226,0.00008718595,0.00001037631,0.00005240694,0.00004829878,4.163829e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006000658,"about_ca_system_score_gemma":0.0001423503,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002018987,"about_ca_topic_score_gemma":0.000002284867,"domain_scores_codex":[0.9991091,0.00007308415,0.0001374383,0.0003944362,0.00009396696,0.0001919912],"domain_scores_gemma":[0.9993259,0.00001377727,0.00005475335,0.0001491669,0.00006113924,0.000395217],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000203947,0.0001235083,0.01549546,0.0001973732,0.00002588786,0.000003729851,0.00003873162,3.357548e-7,0.9815966,0.00002893307,0.0001499407,0.002135501],"study_design_scores_gemma":[0.000578258,0.00009381051,0.003736154,0.00002733774,0.00005945723,0.00001681055,0.00005219307,0.00003495129,0.9938053,0.0000838668,0.001333424,0.0001783639],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9778296,0.02068181,0.0001841357,0.00009011577,0.00002536428,0.0001620109,0.00095362,0.000009009435,0.00006432021],"genre_scores_gemma":[0.9982969,0.0006322642,0.0003359282,0.00004269286,0.00004717743,0.00001794628,0.0004111311,0.00001671106,0.0001993043],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02046723,"threshold_uncertainty_score":0.6456107,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006967777413555831,"score_gpt":0.2059299169743842,"score_spread":0.1989621395608284,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}