{"id":"W3172368633","doi":"10.1096/fasebj.2021.35.s1.01747","title":"Metformin Activates Resident Neural Stem and Progenitor Cells, Reduces Inflammation and Improves Functional Recovery Following Spinal Cord Injury","year":2021,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"Neurogenesis and neuroplasticity mechanisms","field":"Neuroscience","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Muscular Dystrophy Canada; University of Toronto","funders":"","keywords":"Metformin; Spinal cord injury; Neurogenesis; Progenitor cell; Medicine; Inflammation; Neuroprotection; Neural stem cell; Population; Pharmacology; Progenitor; Stem cell; Neuroscience; Spinal cord; Internal medicine; Biology; Cell biology; Insulin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001677103,0.0004018448,0.0005402953,0.0004819933,0.000188176,0.0002528688,0.0002453658,0.0003693762,0.001125917],"category_scores_gemma":[0.0001640989,0.0001326078,0.0003621346,0.0002074208,0.0001862485,0.0002944643,0.0001881222,0.000848082,0.0002012725],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001966209,"about_ca_system_score_gemma":0.0004641812,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005625893,"about_ca_topic_score_gemma":0.001940394,"domain_scores_codex":[0.9998854,0.00001450891,0.00001664231,0.00001541147,0.00003279368,0.00003514778],"domain_scores_gemma":[0.9998968,0.000007986399,0.00003884731,0.000006888937,0.00001351321,0.0000360628],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003458851,0.0009167075,0.0007935848,0.0003715671,0.00004608504,0.00007600464,0.00003144354,0.0002254565,0.9770338,0.0001398007,0.0002376655,0.01666897],"study_design_scores_gemma":[0.000468519,0.01653943,0.02752173,0.00008157574,0.0001810923,0.0002002988,0.0001359846,0.001176258,0.9502789,0.0001538714,0.003239721,0.00002254359],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965447,0.00159621,0.0006001332,0.000136694,0.00005785113,0.00004113538,0.0002588456,0.00004891642,0.0007155109],"genre_scores_gemma":[0.9909666,0.00321198,0.00160449,0.0001574626,0.00004616075,0.0001562097,0.0007004189,0.00001501796,0.003141757],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001125917,"threshold_uncertainty_score":0.003766537,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03944029516187131,"score_gpt":0.2621059717626007,"score_spread":0.2226656766007294,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}