{"id":"W3172387625","doi":"10.1007/s11523-021-00822-5","title":"Risk and Benefit for Targeted Therapy Agents in Pediatric Phase II Trials in Oncology: A Systematic Review with a Meta-Analysis","year":2021,"lang":"en","type":"review","venue":"Targeted Oncology","topic":"Ethics in Clinical Research","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Narodowe Centrum Nauki","keywords":"Medicine; Meta-analysis; Oncology; Targeted therapy; Clinical trial; Internal medicine; Pediatric oncology; Intensive care medicine; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.03423872,0.003305393,0.02251593,0.008481128,0.0006836707,0.004010059,0.002432824,0.002531352,0.003694382],"category_scores_gemma":[0.07986587,0.001896014,0.05429957,0.009739842,0.001067012,0.003134055,0.001990169,0.002446967,0.0003401859],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003149221,"about_ca_system_score_gemma":0.003522711,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004288611,"about_ca_topic_score_gemma":0.008871377,"domain_scores_codex":[0.9658879,0.01935524,0.008714155,0.002648368,0.002836454,0.000557907],"domain_scores_gemma":[0.922038,0.06309611,0.009804789,0.001869502,0.002690835,0.0005007108],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.001774983,0.00001627522,0.00415546,0.2421216,0.7439942,0.0001032152,0.00006169975,0.0006127778,0.0001098043,0.0001515776,0.0004746297,0.006423736],"study_design_scores_gemma":[0.000690057,0.0001408687,0.002346681,0.0174941,0.9777115,0.00006874009,0.00003163472,0.0002768496,0.00006174415,0.0002857911,0.0008718589,0.00002023915],"study_design_candidate":"meta_analysis","study_design_consensus":"meta_analysis","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.005487558,0.9906238,0.001728114,0.0002954484,0.0001736504,0.000664566,0.0006684819,0.000042877,0.0003155268],"genre_scores_gemma":[0.3210655,0.661735,0.008035656,0.001696145,0.0005416544,0.004948238,0.001396307,0.00008329005,0.0004982355],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.03423872,"threshold_uncertainty_score":0.1810738,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.7192358579784843,"score_gpt":0.652057374042999,"score_spread":0.06717848393548531,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}