{"id":"W3172411380","doi":"10.1101/2021.06.12.448150","title":"Alpha-synuclein induces epigenomic dysregulation of glutamate signaling and locomotor pathways","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Bundesministerium für Bildung und Forschung; Deutsche Forschungsgemeinschaft; Canadian Institutes of Health Research; Genome Canada; Canadian Institute for Advanced Research; Deutsches Zentrum für Neurodegenerative Erkrankungen; Agence Nationale de la Recherche; National Institutes of Health; National Science Foundation","keywords":"DNA methylation; Biology; Epigenetics; Dopaminergic; Alpha-synuclein; Epigenomics; Genetics; Transcriptome; Methylation; Regulation of gene expression; Gene; Cell biology; Gene expression; Dopamine; Parkinson's disease; Neuroscience; Internal medicine; Disease; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005949045,0.0001382932,0.0001603888,0.0002564951,0.00009269033,0.0001596322,0.00006928054,0.0001184506,0.0009270568],"category_scores_gemma":[0.00006215028,0.0001044079,0.0001645051,0.0001518525,0.0001056606,0.00005679287,0.0001712205,0.0001881098,0.0001190899],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002069212,"about_ca_system_score_gemma":0.000111818,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008710437,"about_ca_topic_score_gemma":0.001800646,"domain_scores_codex":[0.9999328,0.000009327719,0.000003691005,0.00002593144,0.00001470472,0.00001357603],"domain_scores_gemma":[0.9999242,0.000009091323,0.00003082708,0.000008450093,0.00001265812,0.00001474002],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001653307,0.0000103914,0.004573635,0.00001988918,0.00001847511,0.0000308583,0.00001635219,0.0001116844,0.9935776,0.00004505053,0.00005152567,0.001379052],"study_design_scores_gemma":[0.0000182303,0.0003145408,0.5962369,0.00001334952,0.00006363478,0.000303283,0.0001111669,0.002705977,0.3984937,0.0002517947,0.001478117,0.000009348511],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971358,0.0005172543,0.00123416,0.0000309446,0.000005940689,0.000005364524,0.0005170795,0.00004629096,0.0005072093],"genre_scores_gemma":[0.9975267,0.0002324691,0.0005815098,0.00003726571,0.000002460747,0.00001506183,0.0004944745,0.000008272234,0.001101748],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009270568,"threshold_uncertainty_score":0.003101349,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0140041898574903,"score_gpt":0.2136341771820869,"score_spread":0.1996299873245966,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}