{"id":"W3172460540","doi":"10.3390/v13061084","title":"Examination of the APOBEC3 Barrier to Cross Species Transmission of Primate Lentiviruses","year":2021,"lang":"en","type":"review","venue":"Viruses","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Canadian Institutes of Health Research","keywords":"Cytidine deaminase; APOBEC3G; Biology; Simian immunodeficiency virus; Virology; Restriction enzyme; Cytidine; Virus; Viral replication; DNA; Mutagenesis; Somatic hypermutation; Genetics; Mutation; Enzyme; Antibody; Gene; B cell; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005218066,0.0004824582,0.0006789691,0.001771205,0.0002294244,0.0007653164,0.0006127178,0.0008231813,0.002020559],"category_scores_gemma":[0.0006808265,0.0002253306,0.0002560704,0.001429261,0.0004026846,0.000997887,0.0004891467,0.001366214,0.0009802623],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007446709,"about_ca_system_score_gemma":0.0009678773,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001536708,"about_ca_topic_score_gemma":0.002307233,"domain_scores_codex":[0.9998744,0.00002441689,0.00001491038,0.00002421064,0.00004932748,0.0000127855],"domain_scores_gemma":[0.9997445,0.0001258592,0.00002805348,0.000006732515,0.00007123093,0.00002364563],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005770129,0.00003839792,0.0001850817,0.01461305,0.00006764698,0.0002343712,0.00009934705,0.0003163098,0.002485131,0.007443056,0.02370495,0.9507549],"study_design_scores_gemma":[0.000008275476,0.0000612675,0.0008739919,0.002808593,0.00005498723,0.0008551496,0.00005180836,0.00007707418,0.0004892701,0.001731842,0.9929763,0.00001140688],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001152041,0.9984093,0.00007118534,0.0001816288,0.0001376844,0.000002429268,0.000006516315,0.00000307843,0.001073055],"genre_scores_gemma":[0.0008264796,0.998036,0.0001466917,0.0001913967,0.0001514793,0.00000488176,0.00001705556,0.000001274708,0.0006248477],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002020559,"threshold_uncertainty_score":0.006759465,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08258925611856943,"score_gpt":0.3750619589466153,"score_spread":0.2924727028280459,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}