{"id":"W3172460540","doi":"10.3390/v13061084","title":"Examination of the APOBEC3 Barrier to Cross Species Transmission of Primate Lentiviruses","year":2021,"lang":"en","type":"review","venue":"Viruses","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Canadian Institutes of Health Research","keywords":"Cytidine deaminase; APOBEC3G; Biology; Simian immunodeficiency virus; Virology; Restriction enzyme; Cytidine; Virus; Viral replication; DNA; Mutagenesis; Somatic hypermutation; Genetics; Mutation; Enzyme; Antibody; Gene; B cell; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002518219,0.0002409473,0.000984591,0.0001486162,0.000113505,0.00001511234,0.000359287,0.0002493199,0.001324066],"category_scores_gemma":[0.0001576114,0.0001374553,0.0004307668,0.0003004014,0.000269945,0.00005475713,0.0001600995,0.0002001447,0.0002757258],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005141953,"about_ca_system_score_gemma":0.0002912214,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005074875,"about_ca_topic_score_gemma":0.00001247309,"domain_scores_codex":[0.9982442,0.0006390311,0.0004990538,0.0002752486,0.00009733439,0.0002451293],"domain_scores_gemma":[0.9988897,0.0002870095,0.0002374838,0.0004426672,0.0001169692,0.00002619659],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002185381,0.0002431717,0.0001250461,0.004339242,0.0005930004,0.000004074097,0.0002891546,4.632598e-7,0.01271652,0.0002172959,0.001024074,0.9804261],"study_design_scores_gemma":[0.0001982427,0.0000764175,0.0005970086,0.004249264,0.0002132905,0.000007009408,0.00002227444,6.983418e-9,0.1113155,0.000002105055,0.8832161,0.0001028431],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.002341819,0.9947596,0.00002211556,0.000007360627,0.0002279945,0.0006254015,0.001065201,0.00001342432,0.0009371014],"genre_scores_gemma":[0.001407898,0.9938145,0.00003122232,0.00001650699,0.00001549412,0.00006577133,0.0001449396,0.00002403404,0.004479603],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9803233,"threshold_uncertainty_score":0.9995888,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08258925611856943,"score_gpt":0.3750619589466153,"score_spread":0.2924727028280459,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}