{"id":"W3172575230","doi":"10.1002/dad2.12208","title":"A profile of brain reserve in adults at genetic risk of Alzheimer's disease","year":2021,"lang":"en","type":"article","venue":"Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Centre for Addiction and Mental Health; Baycrest Hospital","funders":"National Center for Advancing Translational Sciences; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; Avid Radiopharmaceuticals; Eli Lilly and Company; National Institute on Aging; National Institutes of Health","keywords":"Apolipoprotein E; Cognitive reserve; Dementia; Precuneus; Alzheimer's disease; Brain size; Psychology; Disease; Cognition; Internal medicine; Medicine; Cardiology; Audiology; Gerontology; Neuroscience; Radiology; Magnetic resonance imaging","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002851455,0.0001892013,0.0002251403,0.0008171351,0.0003028969,0.000368125,0.0001408427,0.000310015,0.001154762],"category_scores_gemma":[0.001371445,0.00009413027,0.0001551878,0.0005195522,0.0001862213,0.0002434753,0.0002231917,0.0001947386,0.0001383708],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001095228,"about_ca_system_score_gemma":0.0001114489,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003242485,"about_ca_topic_score_gemma":0.004544284,"domain_scores_codex":[0.9998795,0.00003077993,0.00001555985,0.00002611948,0.00002408271,0.00002394754],"domain_scores_gemma":[0.999562,0.00007342588,0.0002039417,0.00001925116,0.00004504433,0.00009634838],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002449548,0.00003069407,0.9969931,0.000006196969,0.00003926242,0.0001837192,0.0001012691,0.00003345041,0.0006694617,0.00002351163,0.00005369241,0.001620702],"study_design_scores_gemma":[0.000003797265,0.0001113567,0.9992473,0.000002337378,0.00001347921,0.0003322895,0.00009014085,0.00006119937,0.00005559537,0.0000340861,0.00004678752,0.00000161336],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9996988,0.00007364162,0.00001568703,0.00001513516,8.10016e-7,0.000001511029,0.00005640664,8.028085e-7,0.0001372625],"genre_scores_gemma":[0.9998216,0.00001914023,0.00002514235,0.000009119895,0.000002217623,0.000001285603,0.00006978853,3.437994e-7,0.00005132891],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003242485,"threshold_uncertainty_score":0.006447256,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02552701406741709,"score_gpt":0.3415691926608561,"score_spread":0.316042178593439,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}