{"id":"W3172587474","doi":"10.1097/cji.0000000000000377","title":"Safety and Clinical Outcomes of Immune Checkpoint Inhibitors in Patients With Cancer and Preexisting Autoimmune Diseases","year":2021,"lang":"en","type":"article","venue":"Journal of Immunotherapy","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"Kingston Health Sciences Centre","funders":"","keywords":"Medicine; Cancer; Immunology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005582176,0.000170702,0.0008423603,0.0001281854,0.00004412755,0.00001876463,0.00006710963,0.00008239637,0.00007817301],"category_scores_gemma":[0.0001240259,0.0001146761,0.0002324324,0.0002103133,0.0002211978,0.0001401977,0.00003009835,0.0002800368,9.150338e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009144416,"about_ca_system_score_gemma":0.0003091837,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000174347,"about_ca_topic_score_gemma":0.00002763798,"domain_scores_codex":[0.9978259,0.00009048175,0.001455064,0.0001563717,0.0003072056,0.0001650029],"domain_scores_gemma":[0.9984276,0.0001816538,0.000828448,0.0001982804,0.000294821,0.00006917235],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0122851,0.0005354331,0.8700181,0.0000568331,0.0009186261,0.00002425112,0.0002898968,0.000001895568,0.004242372,0.000002903,0.000009789066,0.1116148],"study_design_scores_gemma":[0.02063547,0.00120303,0.9744102,0.001133653,0.0001161973,0.00003770971,0.0001761345,0.000005884418,0.001235278,0.00001135941,0.0009126589,0.0001224791],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9601906,0.03851596,0.00001695662,0.0007826231,0.0002523694,0.0001865196,0.00001491806,0.000005173672,0.00003486121],"genre_scores_gemma":[0.9792926,0.01963753,0.0006306494,0.0002218954,0.00005922853,0.000002109598,0.000004816768,0.00002701963,0.0001241062],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1114923,"threshold_uncertainty_score":0.4676355,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0129970312827163,"score_gpt":0.3046834379528645,"score_spread":0.2916864066701482,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}