{"id":"W3172682706","doi":"10.1016/j.biopsych.2021.05.027","title":"Developmental and Behavioral Phenotypes in a Mouse Model of DDX3X Syndrome","year":2021,"lang":"en","type":"article","venue":"Biological Psychiatry","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Hospital for Sick Children","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai; National Institute of Neurological Disorders and Stroke; School of Medicine, New York University; National Institutes of Health; Fondation pour la Recherche Médicale; Ontario Brain Institute; Canadian Institutes of Health Research; Philippe Foundation; Fundación Alfonso Martín Escudero; Beatrice and Samuel A. Seaver Foundation; Icahn School of Medicine at Mount Sinai","keywords":"Neuroscience; Haploinsufficiency; Psychology; Prefrontal cortex; Biology; Phenotype; Cognition; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004622581,0.0001124279,0.000131696,0.00002373751,0.00002511014,0.000005896178,0.00008317192,0.0001298178,0.00001587208],"category_scores_gemma":[0.00001268312,0.00009968852,0.00003928206,0.00006009872,0.00007419749,0.000001501427,0.0001461411,0.00005883171,0.000001989153],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005036964,"about_ca_system_score_gemma":0.000104624,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005187557,"about_ca_topic_score_gemma":0.00007509576,"domain_scores_codex":[0.9992661,0.0000268165,0.0001910807,0.0003033585,0.0000563586,0.0001562697],"domain_scores_gemma":[0.9998142,0.000002683938,0.00003385354,0.00008001507,0.00001980331,0.00004946586],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00003956743,0.0002677878,0.1357143,0.00001131977,0.000009898376,0.000002486616,0.00002165026,0.00003183364,0.8631929,0.0001517317,0.00007389238,0.0004826607],"study_design_scores_gemma":[0.001669154,0.0006748905,0.8644687,0.00002561434,0.00001107245,0.00008647094,0.000586765,0.0001239188,0.1296182,0.001715315,0.0004544645,0.0005654025],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984668,0.0008747322,0.00006414547,0.00007974068,0.00005858146,0.00007271643,0.00003015966,0.000004734773,0.0003483376],"genre_scores_gemma":[0.9880729,0.0003837047,0.01105726,0.0002346809,0.000004696545,0.000008466397,0.00005221613,0.000008307878,0.0001778225],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7335746,"threshold_uncertainty_score":0.406518,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02853947847243337,"score_gpt":0.2592966140831447,"score_spread":0.2307571356107113,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}