{"id":"W3172682706","doi":"10.1016/j.biopsych.2021.05.027","title":"Developmental and Behavioral Phenotypes in a Mouse Model of DDX3X Syndrome","year":2021,"lang":"en","type":"article","venue":"Biological Psychiatry","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Hospital for Sick Children","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai; National Institute of Neurological Disorders and Stroke; School of Medicine, New York University; National Institutes of Health; Fondation pour la Recherche Médicale; Ontario Brain Institute; Canadian Institutes of Health Research; Philippe Foundation; Fundación Alfonso Martín Escudero; Beatrice and Samuel A. Seaver Foundation; Icahn School of Medicine at Mount Sinai","keywords":"Neuroscience; Haploinsufficiency; Psychology; Prefrontal cortex; Biology; Phenotype; Cognition; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004098868,0.001622704,0.0003640748,0.002178056,0.0004841792,0.0004118777,0.0005361583,0.001179541,0.003487767],"category_scores_gemma":[0.0002852312,0.000365688,0.0004275185,0.0003908423,0.0007809685,0.0003682728,0.0005957565,0.001222115,0.0006220085],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006611141,"about_ca_system_score_gemma":0.0005233999,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001027499,"about_ca_topic_score_gemma":0.002202411,"domain_scores_codex":[0.9995685,0.00005736065,0.00006242339,0.0001139506,0.0001382104,0.00005950877],"domain_scores_gemma":[0.9996044,0.00005817775,0.0001349287,0.00003176171,0.00003404409,0.0001366741],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002930178,0.0002347256,0.001063959,0.00006233154,0.00002356055,0.000969867,0.0000900765,0.000244848,0.9937318,0.0006819345,0.0002511897,0.002352611],"study_design_scores_gemma":[0.0003320717,0.00250547,0.03125363,0.0001421799,0.0001849433,0.0109129,0.0002654168,0.003781212,0.9383422,0.0009221848,0.01130795,0.00004987091],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9851575,0.001059911,0.006619135,0.0004817567,0.00009310467,0.0001893318,0.003071067,0.000540166,0.002788031],"genre_scores_gemma":[0.9642914,0.001419584,0.01530936,0.0003534855,0.00003285194,0.0007197636,0.003825023,0.0003514344,0.01369704],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003487767,"threshold_uncertainty_score":0.01166773,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02853947847243337,"score_gpt":0.2592966140831447,"score_spread":0.2307571356107113,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}