{"id":"W3172691600","doi":"10.1038/s41590-021-00943-z","title":"Blockade of the co-inhibitory molecule PD-1 unleashes ILC2-dependent antitumor immunity in melanoma","year":2021,"lang":"en","type":"article","venue":"Nature Immunology","topic":"IL-33, ST2, and ILC Pathways","field":"Immunology and Microbiology","cited_by":175,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre","funders":"Diamantina Institute, University of Queensland; Cancer Biology Research Center, Tel Aviv University; Medical Research Council; CSL Limited; Emerson Collective; Allergan; U.S. Department of Health and Human Services; Cure Cancer Australia Foundation; State Government of Victoria; Australian Government; John T. Reid Charitable Trusts; Deutsche Forschungsgemeinschaft; Israel Cancer Association; Bristol-Myers Squibb; Cancer Council NSW; National Health and Medical Research Council; Israel Science Foundation; Israel Cancer Research Fund; Cancer Australia; University of Queensland; National Science Foundation; Genentech; Victorian Cancer Agency","keywords":"Innate lymphoid cell; Melanoma; Cytokine; Immune system; Immunology; Cancer research; Biology; Immunotherapy; Innate immune system; Blockade; Tumor microenvironment; Cancer immunotherapy; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":["research_integrity"],"category_scores_codex":[0.0003426511,0.0003170027,0.0006105667,0.0001785012,0.000255532,0.00001104746,0.0007455472,0.001439369,0.0003348539],"category_scores_gemma":[0.0005457035,0.0002531688,0.0002177459,0.0004694413,0.000673305,0.00008192418,0.0004103163,0.002654909,0.000207066],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001027908,"about_ca_system_score_gemma":0.000524675,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002055351,"about_ca_topic_score_gemma":0.0003984645,"domain_scores_codex":[0.9972491,0.00102256,0.0005590788,0.0004617027,0.00008905495,0.0006185565],"domain_scores_gemma":[0.9982672,0.0002329898,0.0002577282,0.0009898683,0.0002340654,0.00001814158],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002046349,0.0003898857,0.00714898,0.00003867458,0.0002633445,0.00008521308,0.0006174959,0.000003337282,0.9871994,0.002344976,0.00127323,0.0004308786],"study_design_scores_gemma":[0.001925554,0.0001438184,0.06674517,0.00007518011,0.00004202464,0.0004634412,0.0007763841,5.964786e-7,0.8847344,0.0002768095,0.04457298,0.0002436287],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9593054,0.02841721,0.000006743096,0.0003925967,0.00292444,0.000244448,0.0006051052,0.00005704339,0.008046987],"genre_scores_gemma":[0.9961696,0.0005021387,0.00003360094,0.0003546546,0.00005789095,0.00001870641,0.0001706668,0.00002947991,0.002663315],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1024649,"threshold_uncertainty_score":0.9999921,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005442067481117883,"score_gpt":0.225703749468708,"score_spread":0.2202616819875901,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}