{"id":"W3172691600","doi":"10.1038/s41590-021-00943-z","title":"Blockade of the co-inhibitory molecule PD-1 unleashes ILC2-dependent antitumor immunity in melanoma","year":2021,"lang":"en","type":"article","venue":"Nature Immunology","topic":"IL-33, ST2, and ILC Pathways","field":"Immunology and Microbiology","cited_by":175,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre","funders":"Diamantina Institute, University of Queensland; Cancer Biology Research Center, Tel Aviv University; Medical Research Council; CSL Limited; Emerson Collective; Allergan; U.S. Department of Health and Human Services; Cure Cancer Australia Foundation; State Government of Victoria; Australian Government; John T. Reid Charitable Trusts; Deutsche Forschungsgemeinschaft; Israel Cancer Association; Bristol-Myers Squibb; Cancer Council NSW; National Health and Medical Research Council; Israel Science Foundation; Israel Cancer Research Fund; Cancer Australia; University of Queensland; National Science Foundation; Genentech; Victorian Cancer Agency","keywords":"Innate lymphoid cell; Melanoma; Cytokine; Immune system; Immunology; Cancer research; Biology; Immunotherapy; Innate immune system; Blockade; Tumor microenvironment; Cancer immunotherapy; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001616107,0.0003274897,0.0002576227,0.0001901553,0.0001700432,0.0003279418,0.0001297505,0.0002369396,0.001337912],"category_scores_gemma":[0.0001311724,0.0001065412,0.0001615138,0.00009482334,0.0001953041,0.0001735134,0.0001886359,0.001451234,0.000312954],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002862743,"about_ca_system_score_gemma":0.0003968675,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004930195,"about_ca_topic_score_gemma":0.001684447,"domain_scores_codex":[0.9998627,0.00002444834,0.000006860007,0.00001403701,0.0000338236,0.00005806119],"domain_scores_gemma":[0.9999238,0.00001155958,0.00001331286,0.000009257448,0.000006876533,0.00003507693],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001164396,0.0003487951,0.0005814949,0.00007505866,0.00001571787,0.0001127436,0.00002261243,0.0007315638,0.9834788,0.0005233954,0.0007970672,0.01214834],"study_design_scores_gemma":[0.000360386,0.002531079,0.01182631,0.00002455305,0.00004482478,0.0004636923,0.00008386232,0.006675004,0.9662664,0.0005249669,0.01118665,0.00001222735],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922873,0.001663403,0.001623838,0.0003432444,0.00009824603,0.00003857024,0.0002052313,0.0001210965,0.003619014],"genre_scores_gemma":[0.9972958,0.0005096839,0.000476082,0.00008719497,0.00002454625,0.00002666936,0.0001416425,0.00001131796,0.001427081],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001337912,"threshold_uncertainty_score":0.004475772,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005442067481117883,"score_gpt":0.225703749468708,"score_spread":0.2202616819875901,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}