{"id":"W3172702717","doi":"10.1016/j.isci.2021.102699","title":"A novel mouse AAV6 hACE2 transduction model of wild-type SARS-CoV-2 infection studied using synDNA immunogens","year":2021,"lang":"en","type":"article","venue":"iScience","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph; University of Manitoba; Public Health Agency of Canada","funders":"National Institute of Allergy and Infectious Diseases; National Cancer Institute; National Institutes of Health","keywords":"Transduction (biophysics); Immunology; Biology; Virology; Respiratory tract; Virus; Attenuated vaccine; Respiratory system; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004137557,0.0001410732,0.0002770286,0.0001930604,0.0001732953,0.00003276569,0.0001253768,0.00008661472,0.000002946421],"category_scores_gemma":[0.000275287,0.0001308506,0.0001094498,0.001261394,0.0002628606,0.0002613275,0.00007494696,0.0002092336,0.00001130127],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001885583,"about_ca_system_score_gemma":0.0007651896,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007822294,"about_ca_topic_score_gemma":0.0001757214,"domain_scores_codex":[0.9983133,0.00003583953,0.0002815387,0.0004194991,0.0006150994,0.0003347219],"domain_scores_gemma":[0.9989614,0.00003434751,0.00007755253,0.00040322,0.0004983171,0.00002519378],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000103935,0.0003036831,0.002641352,0.0000735666,0.00004598875,0.00001128418,0.0007066478,0.0004598774,0.9941555,0.00005509898,0.00002221222,0.001420819],"study_design_scores_gemma":[0.0007414508,0.0001427224,0.0008664053,0.00007185539,0.00007459215,0.000112372,0.0001100958,0.08913725,0.9079832,0.00005008452,0.0005920954,0.0001178644],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9696652,0.0005525685,0.02857905,0.0001541671,0.0002174983,0.0002263412,0.000005552497,0.00004936237,0.0005502492],"genre_scores_gemma":[0.9953296,0.00002529734,0.002416783,0.002093757,0.00005331227,0.00000711341,0.000001348796,0.00001738049,0.00005541741],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08867737,"threshold_uncertainty_score":0.5335935,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1320082962118558,"score_gpt":0.382444950603086,"score_spread":0.2504366543912302,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}