{"id":"W3172723316","doi":"10.1101/2021.06.12.448196","title":"Exposure route, sex, and age influence disease outcome in a golden Syrian hamster model of SARS-CoV-2 infection","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"COVID-19 Clinical Research Studies","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sunnybrook Hospital; University of Toronto; Canadian Science Centre for Human and Animal Health; Canadian Food Inspection Agency; Sunnybrook Health Science Centre; University of Manitoba; Public Health Agency of Canada","funders":"","keywords":"Respiratory tract; Medicine; Hamster; Nasal administration; Titer; Mesocricetus; Viral shedding; Immunology; Disease; Virology; Pathogenesis; Respiratory system; Golden hamster; Physiology; Internal medicine; Virus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000239495,0.0005292683,0.0004818194,0.0004721896,0.0002207334,0.0003751618,0.0001784244,0.0004420705,0.001429992],"category_scores_gemma":[0.0001628496,0.0001947684,0.0004504817,0.0001615225,0.0003011769,0.0003920151,0.0002708717,0.0007243838,0.0003470529],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003293492,"about_ca_system_score_gemma":0.0002479789,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001158699,"about_ca_topic_score_gemma":0.002430121,"domain_scores_codex":[0.9997957,0.00002828521,0.00002052395,0.00005323118,0.00003845017,0.00006372955],"domain_scores_gemma":[0.9997491,0.00002398555,0.0000718537,0.00002377698,0.00002650987,0.0001048202],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003708837,0.0009030494,0.009907991,0.00008128848,0.00003668378,0.0002749589,0.0001554351,0.0001261557,0.9815257,0.00006990352,0.0002020198,0.003007919],"study_design_scores_gemma":[0.0003361415,0.03292942,0.384215,0.00006020091,0.0003269016,0.001081706,0.000790532,0.00303404,0.5725728,0.0002771431,0.004282907,0.00009317939],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984905,0.0004160537,0.0001537158,0.00004870659,0.00002923283,0.00002324558,0.0004742259,0.00001238079,0.0003518742],"genre_scores_gemma":[0.9954497,0.0004796861,0.000330205,0.0001027666,0.00001636525,0.00007188563,0.0005831531,0.0000124472,0.002953767],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001429992,"threshold_uncertainty_score":0.004783869,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05964782348605951,"score_gpt":0.3501264632530554,"score_spread":0.2904786397669959,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}