{"id":"W3172779990","doi":"10.1177/17588359211019675","title":"Selpercatinib in RET fusion-positive non-small-cell lung cancer (SIREN): a retrospective analysis of patients treated through an access program","year":2021,"lang":"en","type":"article","venue":"Therapeutic Advances in Medical Oncology","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"Regional Municipality of Durham; Lakeridge Health; Queen's University; University of Manitoba; Research Institute in Oncology and Hematology; CancerCare Manitoba","funders":"Karl Landsteiner Privatuniversität für Gesundheitswissenschaften","keywords":"Medicine; Internal medicine; Brain metastasis; Lung cancer; Oncology; Adverse effect; Retrospective cohort study; Confidence interval; Population; Fusion gene; Cancer; Metastasis; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000864635,0.0002158308,0.0004477352,0.0008172177,0.0003489018,0.0006388723,0.0002581619,0.0003529655,0.001034962],"category_scores_gemma":[0.001229222,0.0002693325,0.0005500669,0.0009849089,0.0003156439,0.0004488608,0.0004946525,0.000326631,0.0002319092],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003150837,"about_ca_system_score_gemma":0.0003280734,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001478229,"about_ca_topic_score_gemma":0.001663427,"domain_scores_codex":[0.9992115,0.0001832582,0.0001311428,0.0002318594,0.0001509537,0.0000912439],"domain_scores_gemma":[0.9985429,0.0003372049,0.0006932245,0.0001219281,0.0001333461,0.0001713661],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005152251,0.00005726366,0.996987,0.00001740482,0.00009365012,0.0002870568,0.00005922017,0.00006182455,0.000316633,0.00001553681,0.00008243144,0.001506716],"study_design_scores_gemma":[0.00004690039,0.0007415898,0.9963141,0.00001167591,0.0001118022,0.001576852,0.0001900892,0.0002686133,0.0002440212,0.00001791865,0.0004690855,0.000007322307],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991924,0.0002507414,0.00005028894,0.000009415612,0.000001749443,0.00001383103,0.0002748613,0.000001943839,0.0002046269],"genre_scores_gemma":[0.9992328,0.0001231673,0.00003082322,0.00002214957,0.000005307008,0.00001195507,0.0005113051,0.000001472342,0.00006101561],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001478229,"threshold_uncertainty_score":0.00457269,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01930944574526549,"score_gpt":0.4443961404085657,"score_spread":0.4250866946633002,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}