{"id":"W3172779990","doi":"10.1177/17588359211019675","title":"Selpercatinib in RET fusion-positive non-small-cell lung cancer (SIREN): a retrospective analysis of patients treated through an access program","year":2021,"lang":"en","type":"article","venue":"Therapeutic Advances in Medical Oncology","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"Regional Municipality of Durham; Lakeridge Health; Queen's University; University of Manitoba; Research Institute in Oncology and Hematology; CancerCare Manitoba","funders":"Karl Landsteiner Privatuniversität für Gesundheitswissenschaften","keywords":"Medicine; Internal medicine; Brain metastasis; Lung cancer; Oncology; Adverse effect; Retrospective cohort study; Confidence interval; Population; Fusion gene; Cancer; Metastasis; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000197996,0.0002153549,0.0009827344,0.0002423396,0.00004897046,0.000008207877,0.0001854636,0.0002590962,0.0008445082],"category_scores_gemma":[0.00007903297,0.000169541,0.0001230385,0.0021694,0.000228457,0.000269951,0.00007014615,0.0003773371,8.736714e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00107493,"about_ca_system_score_gemma":0.001138996,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006642138,"about_ca_topic_score_gemma":0.006528156,"domain_scores_codex":[0.9977747,0.0002722831,0.0006115414,0.0005368158,0.0004425074,0.0003621545],"domain_scores_gemma":[0.9987292,0.0002386954,0.0002387978,0.00029173,0.0003424393,0.0001591335],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004493848,0.005231598,0.7997174,0.00007438366,0.0008798231,0.0002125644,0.005434909,0.0001014177,0.00006918192,0.00009568971,0.000006995213,0.1877266],"study_design_scores_gemma":[0.008995027,0.002088816,0.9754816,0.0003004055,0.003156001,0.000004793971,0.001073107,0.005345423,0.000876024,0.0002928401,0.002164836,0.0002211247],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9856169,0.004548731,0.0003696743,0.00089959,0.000204072,0.00117203,0.00007267502,0.00003437091,0.007081989],"genre_scores_gemma":[0.9885898,0.007589452,0.001292893,0.00131026,0.00005409409,0.0005891241,0.0004649938,0.00002266219,0.00008678054],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1875055,"threshold_uncertainty_score":0.9246773,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01930944574526549,"score_gpt":0.4443961404085657,"score_spread":0.4250866946633002,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}