{"id":"W3172857299","doi":"10.1038/s42003-021-02227-6","title":"Prioritization of candidate causal genes for asthma in susceptibility loci derived from UK Biobank","year":2021,"lang":"en","type":"article","venue":"Communications Biology","topic":"Asthma and respiratory diseases","field":"Medicine","cited_by":174,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; St. Paul's Hospital; Université Laval; Institut universitaire de cardiologie et de pneumologie de Québec","funders":"Medical Research Council; Fonds de Recherche du Québec - Santé; Institut universitaire de cardiologie et de pneumologie de Québec, Université Laval; Canadian Institutes of Health Research; Université Laval","keywords":"Biobank; Prioritization; Asthma; Genetics; Gene; Candidate gene; Computational biology; Biology; Immunology; Engineering; Management science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000956709,0.00007211205,0.0002287765,0.0000574758,0.00006627544,0.00000331718,0.0001695509,0.000107243,0.00009456851],"category_scores_gemma":[0.0002775203,0.00006629604,0.00006133262,0.0001677134,0.0002693956,0.0000184019,0.000137397,0.00007297608,0.000003534787],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004048659,"about_ca_system_score_gemma":0.0002960843,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002369161,"about_ca_topic_score_gemma":0.00280625,"domain_scores_codex":[0.9992142,0.0001927321,0.0002829646,0.0001677192,0.00003078265,0.0001116079],"domain_scores_gemma":[0.9984397,0.0002137676,0.00008260473,0.0009726167,0.0002432043,0.00004811041],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00009709963,0.0003131951,0.6168418,0.0000405627,0.0000375368,0.000001957384,0.000166205,0.000003796023,0.3613473,0.0009322878,0.0001066107,0.02011173],"study_design_scores_gemma":[0.0023529,0.0002606928,0.8915333,0.00008106648,0.00007570976,0.000005948156,0.0007648669,0.0007168185,0.07370716,0.001839299,0.02849341,0.0001688783],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9860451,0.009519357,0.002524339,0.001099486,0.00005225508,0.0002900896,0.0002905954,0.00001788712,0.0001608494],"genre_scores_gemma":[0.9895309,0.0008240874,0.006927063,0.0001767631,0.00003443233,0.00004637626,0.00242607,0.000007406582,0.00002690968],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2876401,"threshold_uncertainty_score":0.2703474,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0359188883477214,"score_gpt":0.3403729715396533,"score_spread":0.3044540831919319,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}