{"id":"W3173018072","doi":"10.1200/jco.2021.39.15_suppl.9523","title":"Effects of baseline lactate dehydrogenase (LDH), interferon gamma (IFN-g) expression, and tumor mutational burden (TMB) on treatment response to first-line atezolizumab (A) + vemurafenib (V) and cobimetinib (C) in <i>BRAF</i><sup>V600</sup> mutation–positive advanced melanoma.","year":2021,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Roche (Canada)","funders":"F. Hoffmann-La Roche","keywords":"Medicine; Hazard ratio; Internal medicine; Lactate dehydrogenase; Atezolizumab; Vemurafenib; Oncology; Cancer; Metastatic melanoma; Pembrolizumab; Immunotherapy; Confidence interval; Enzyme; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002691334,0.0004139518,0.0004602633,0.0001926633,0.0001092119,0.0004617242,0.0004019036,0.0003832644,0.001713272],"category_scores_gemma":[0.002732949,0.0001563036,0.001154272,0.0001516012,0.0002598208,0.0002940536,0.0002330678,0.000809529,0.0002320543],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005261101,"about_ca_system_score_gemma":0.0004854739,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001384309,"about_ca_topic_score_gemma":0.001527568,"domain_scores_codex":[0.9993568,0.0003921857,0.00002489116,0.00009351378,0.0000416138,0.00009099974],"domain_scores_gemma":[0.9970847,0.001871756,0.0004667898,0.0001614934,0.00005662485,0.0003587618],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.2439942,0.003086487,0.675228,0.0001666075,0.003562532,0.0001439781,0.0001312122,0.01187187,0.007406058,0.0001524491,0.001046286,0.05321036],"study_design_scores_gemma":[0.003251565,0.04944042,0.8987665,0.00004828869,0.002327123,0.0003782767,0.00010038,0.03942686,0.004682823,0.0004868406,0.001048286,0.00004273223],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990515,0.000235229,0.0001554495,0.00003500711,0.000005848161,0.0000165597,0.000321173,0.000007572638,0.0001716244],"genre_scores_gemma":[0.9994696,0.00003394808,0.0001088728,0.00001529256,0.000003474755,0.00001744611,0.0002335068,0.000001560178,0.0001162468],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002691334,"threshold_uncertainty_score":0.01423329,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0217354365230247,"score_gpt":0.3452379577453137,"score_spread":0.323502521222289,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}