{"id":"W3173110589","doi":"10.1200/jco.2021.39.15_suppl.2509","title":"Phase Ib study of the anti-TGF-β monoclonal antibody (mAb) NIS793 combined with spartalizumab (PDR001), a PD-1 inhibitor, in patients (pts) with advanced solid tumors.","year":2021,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"Novartis","keywords":"Medicine; Tolerability; Lung cancer; Internal medicine; Cancer; Monoclonal antibody; Oncology; Pharmacology; Antibody; Adverse effect; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007326604,0.0009642632,0.0013913,0.0003245284,0.0003408332,0.0007632105,0.0006368877,0.001006031,0.003018636],"category_scores_gemma":[0.0004027904,0.0004488092,0.0009882771,0.0003146206,0.0008052725,0.000677162,0.0003528883,0.002511471,0.001029769],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009548431,"about_ca_system_score_gemma":0.001614448,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001236697,"about_ca_topic_score_gemma":0.002282282,"domain_scores_codex":[0.9997926,0.00007177354,0.00001040965,0.00004115618,0.00002163061,0.00006256696],"domain_scores_gemma":[0.9996964,0.00003700976,0.00004454592,0.00002995467,0.00002354773,0.0001684952],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.6314806,0.119925,0.007757667,0.0007599036,0.0009978352,0.0005088199,0.0004216677,0.005100107,0.1264677,0.0004962495,0.004712951,0.1013715],"study_design_scores_gemma":[0.2169634,0.7591648,0.008565558,0.0000268989,0.000322746,0.000375887,0.00008113312,0.001486175,0.008990473,0.0002389791,0.003765067,0.00001890132],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9921765,0.001208975,0.0006051962,0.0003429066,0.0001212292,0.00231629,0.0007685052,0.00009481173,0.002365639],"genre_scores_gemma":[0.9923184,0.000901603,0.001021779,0.0004500148,0.00009035195,0.001731158,0.001270436,0.00002206274,0.002194206],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003018636,"threshold_uncertainty_score":0.0100984,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04631767264630706,"score_gpt":0.4352997352500569,"score_spread":0.3889820626037498,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}