{"id":"W3173115656","doi":"10.1093/schizbullopen/sgab017","title":"Baseline Levels of C-Reactive Protein and Proinflammatory Cytokines Are Not Associated With Early Response to Amisulpride in Patients With First Episode Psychosis: The OPTiMiSE Cohort Study","year":2021,"lang":"en","type":"article","venue":"Schizophrenia Bulletin Open","topic":"Tryptophan and brain disorders","field":"Neuroscience","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Cilag; École des Neurosciences Paris Île de France; Servier; Lundbeckfonden; Gedeon Richter; Ministerio de Economía y Competitividad; Agence Nationale de la Recherche; Allergan; Fondation FondaMental; Ministerio de Ciencia e Innovación; Fondation de France; Teva Pharmaceutical Industries; Sanofi; European Commission; H. Lundbeck A/S; Fundación Alicia Koplowitz; Instituto de Salud Carlos III; Amgen; Pfizer; Les Laboratories Pierre Fabre; AstraZeneca; Eli Lilly and Company; Bristol-Myers Squibb","keywords":"Amisulpride; Medicine; Proinflammatory cytokine; Confounding; Internal medicine; Schizophrenia (object-oriented programming); Psychosis; Logistic regression; Positive and Negative Syndrome Scale; Biomarker; Depression (economics); C-reactive protein; Antipsychotic; Inflammation; Psychiatry","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001250143,0.0005591551,0.0008236533,0.0004423804,0.000500328,0.0008909497,0.0004889689,0.0006721645,0.001577901],"category_scores_gemma":[0.00236514,0.0005810177,0.001080278,0.0004290544,0.0003241081,0.0004793975,0.0006183924,0.001003943,0.0002546418],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003136374,"about_ca_system_score_gemma":0.0002934789,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002726463,"about_ca_topic_score_gemma":0.003379289,"domain_scores_codex":[0.9994085,0.0002078683,0.00005274685,0.0001415569,0.0000969252,0.00009230956],"domain_scores_gemma":[0.998472,0.0003003377,0.0005567791,0.000292887,0.00009765839,0.000280288],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.007050239,0.000283797,0.9886383,0.00002762104,0.0004558593,0.000182431,0.000169643,0.00009190985,0.001161427,0.00002555035,0.0001945926,0.00171863],"study_design_scores_gemma":[0.0002207617,0.0006737248,0.9980658,0.000009155328,0.0001380539,0.0002199847,0.0001087746,0.0002739036,0.0001269959,0.00002905448,0.0001222592,0.00001156867],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9994519,0.0001093716,0.0000633506,0.00002153499,0.000004804153,0.00001248783,0.0002481909,0.000001621794,0.00008671603],"genre_scores_gemma":[0.9993666,0.0000464589,0.00007811844,0.00001969345,0.000009148998,0.00001254875,0.0003592239,0.000002014988,0.0001061785],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002726463,"threshold_uncertainty_score":0.006611466,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01657021331222588,"score_gpt":0.241597455817276,"score_spread":0.2250272425050501,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}