{"id":"W3173131672","doi":"10.1055/a-1517-7177","title":"Protecting-Group-Free Synthesis of GB1107: An Orally Active Galectin-3 Antagonist","year":2021,"lang":"en","type":"article","venue":"Synthesis","topic":"Galectins and Cancer Biology","field":"Immunology and Microbiology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Natural Sciences and Engineering Research Council of Canada; Université Laval","keywords":"Chemistry; Antagonist; Context (archaeology); Lipophilicity; Orally active; Combinatorial chemistry; Stereochemistry; Protecting group; Pharmacology; Organic chemistry; Biochemistry; In vitro","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001512026,0.0004714918,0.0002693985,0.0002528905,0.0001070081,0.0001831546,0.0002731192,0.0002509869,0.002079396],"category_scores_gemma":[0.0001467171,0.0001072209,0.0002447477,0.0002424916,0.0001419166,0.0001975885,0.0002682827,0.0005874662,0.00110392],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001745318,"about_ca_system_score_gemma":0.0003299473,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004832079,"about_ca_topic_score_gemma":0.0005641088,"domain_scores_codex":[0.9999282,0.00001305201,0.000005301628,0.00001022126,0.0000170611,0.00002614228],"domain_scores_gemma":[0.9999517,0.000005629581,0.00001061293,0.000006929762,0.000009747437,0.00001538714],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001224275,0.0000736626,0.00005942746,0.0001774904,0.00001729932,0.0001732174,0.00003232275,0.0006302469,0.9892264,0.0008300089,0.000309668,0.008347788],"study_design_scores_gemma":[0.00006329024,0.001017609,0.000557269,0.00002162966,0.00003631834,0.0003102554,0.0000209332,0.0008955641,0.9827655,0.0003205328,0.01396879,0.00002231164],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9078016,0.005063305,0.06214751,0.0004751584,0.0001835695,0.0005828912,0.002849875,0.000645028,0.02025115],"genre_scores_gemma":[0.966421,0.003589276,0.02062523,0.0002407547,0.00002712725,0.0002248353,0.001664109,0.0001111752,0.007096508],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002079396,"threshold_uncertainty_score":0.006956279,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01269854759568171,"score_gpt":0.2385238108545848,"score_spread":0.2258252632589031,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}