{"id":"W3173131672","doi":"10.1055/a-1517-7177","title":"Protecting-Group-Free Synthesis of GB1107: An Orally Active Galectin-3 Antagonist","year":2021,"lang":"en","type":"article","venue":"Synthesis","topic":"Galectins and Cancer Biology","field":"Immunology and Microbiology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Natural Sciences and Engineering Research Council of Canada; Université Laval","keywords":"Chemistry; Antagonist; Context (archaeology); Lipophilicity; Orally active; Combinatorial chemistry; Stereochemistry; Protecting group; Pharmacology; Organic chemistry; Biochemistry; In vitro","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0004467874,0.0002939154,0.0006482968,0.0001282329,0.0003736814,0.00002176935,0.0005238314,0.0004293015,0.002619845],"category_scores_gemma":[0.002348284,0.0002712608,0.0002196442,0.0003440655,0.0003503955,0.0001158772,0.0001940337,0.0004223219,0.0001128163],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007697258,"about_ca_system_score_gemma":0.0002288185,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004303288,"about_ca_topic_score_gemma":0.0009053419,"domain_scores_codex":[0.9973707,0.0009367037,0.0004338484,0.0006548766,0.00006380538,0.0005400221],"domain_scores_gemma":[0.9976033,0.0009143625,0.0002836598,0.0009250669,0.0002268801,0.00004674034],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004423905,0.0004163049,0.002184529,0.00006633735,0.0004271883,0.00002157576,0.0002896583,0.000001300341,0.8705708,0.0004467781,0.0006029645,0.1245302],"study_design_scores_gemma":[0.0004037205,0.0002736754,0.01037598,0.00007918198,0.0001540732,0.0002041491,0.001223593,0.000001353247,0.9771535,0.0005086033,0.009310697,0.0003114949],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9804063,0.001643863,0.0001724673,0.0007323338,0.0009217254,0.0003932542,0.00030338,0.0001883079,0.01523833],"genre_scores_gemma":[0.9978394,0.0001036871,0.000771569,0.00009401857,0.00008029382,0.000222674,0.00002809542,0.0000428958,0.0008173554],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1242187,"threshold_uncertainty_score":0.999974,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01269854759568171,"score_gpt":0.2385238108545848,"score_spread":0.2258252632589031,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}