{"id":"W3173169898","doi":"10.3389/fmolb.2021.676235","title":"Ubiquitin Interacting Motifs: Duality Between Structured and Disordered Motifs","year":2021,"lang":"en","type":"article","venue":"Frontiers in Molecular Biosciences","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"FP7 People: Marie-Curie Actions; Novo Nordisk Fonden; Carlsbergfondet; Danmarks Grundforskningsfond; Canadian Institutes of Health Research; European Cooperation in Science and Technology","keywords":"Ubiquitin; Deubiquitinating enzyme; Intrinsically disordered proteins; Structural motif; WW domain; Computational biology; Protein–protein interaction; Ubiquitin-Protein Ligases; Interactome; Ubiquitins; Ubiquitin ligase; Biology; Plasma protein binding; Cell biology; Chemistry; Biophysics; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000411382,0.0002064222,0.0002468566,0.00009203504,0.0001342723,0.0001169031,0.0002865882,0.0001663351,0.0000145652],"category_scores_gemma":[0.0005121054,0.0002046855,0.00007768129,0.0003284395,0.0002770675,0.00001456307,0.0002900917,0.0001691366,0.000001044039],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001815852,"about_ca_system_score_gemma":0.0001199799,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002548524,"about_ca_topic_score_gemma":0.00004193787,"domain_scores_codex":[0.9981412,0.0002411375,0.0002929938,0.0007004503,0.0002321041,0.0003920822],"domain_scores_gemma":[0.9993614,0.00001783127,0.000107204,0.0003247976,0.00006550226,0.0001232441],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002063111,0.00004138687,0.1740935,0.00004730117,0.00004154484,0.00004350279,0.0003730262,0.00003333496,0.8069044,0.0001063632,0.0003572881,0.01793773],"study_design_scores_gemma":[0.0004780416,0.0001149144,0.02110468,0.00004798385,0.00001637551,0.00002119889,0.001885888,0.0002660667,0.9702415,0.00179546,0.003671707,0.000356205],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9709303,0.00246672,0.02478352,0.0003802591,0.0005081804,0.0001754099,0.00004536586,0.00001567689,0.0006945903],"genre_scores_gemma":[0.9761734,0.0001266609,0.02315155,0.0002268823,0.00008834813,0.00001308167,0.00008895228,0.00001633693,0.0001147747],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1633371,"threshold_uncertainty_score":0.8346834,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01020683392863259,"score_gpt":0.2541130357866435,"score_spread":0.2439062018580109,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}