{"id":"W3173169898","doi":"10.3389/fmolb.2021.676235","title":"Ubiquitin Interacting Motifs: Duality Between Structured and Disordered Motifs","year":2021,"lang":"en","type":"article","venue":"Frontiers in Molecular Biosciences","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"FP7 People: Marie-Curie Actions; Novo Nordisk Fonden; Carlsbergfondet; Danmarks Grundforskningsfond; Canadian Institutes of Health Research; European Cooperation in Science and Technology","keywords":"Ubiquitin; Deubiquitinating enzyme; Intrinsically disordered proteins; Structural motif; WW domain; Computational biology; Protein–protein interaction; Ubiquitin-Protein Ligases; Interactome; Ubiquitins; Ubiquitin ligase; Biology; Plasma protein binding; Cell biology; Chemistry; Biophysics; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009879767,0.0002113249,0.0002056134,0.0002080151,0.0002008886,0.0004536421,0.0002564176,0.0002915315,0.0006705381],"category_scores_gemma":[0.0001715863,0.0001186097,0.0001328158,0.0002463362,0.0004077474,0.0005739817,0.0002444613,0.0002910802,0.0002436407],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002129929,"about_ca_system_score_gemma":0.0001453128,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001911858,"about_ca_topic_score_gemma":0.0002795591,"domain_scores_codex":[0.9999322,0.00001409075,0.000004135403,0.00002156915,0.00001514329,0.00001290581],"domain_scores_gemma":[0.9999291,0.00001460406,0.0000202129,0.000009528652,0.00000683139,0.000019744],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008486582,0.0001153029,0.006190561,0.0003943234,0.00008001682,0.001286425,0.000244304,0.01168261,0.8287206,0.113004,0.00128384,0.03614939],"study_design_scores_gemma":[0.0002329162,0.001057735,0.02399479,0.0001276979,0.0001601938,0.006180022,0.0005374753,0.1772109,0.5294646,0.1838892,0.07697256,0.0001720035],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9255645,0.006928627,0.05945243,0.0002533789,0.00006565763,0.0000448901,0.000483678,0.0003771319,0.006829684],"genre_scores_gemma":[0.9822732,0.000800266,0.01534014,0.00011532,0.00001402579,0.00002370596,0.0002330249,0.00002783234,0.001172517],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006705381,"threshold_uncertainty_score":0.002243221,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01020683392863259,"score_gpt":0.2541130357866435,"score_spread":0.2439062018580109,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}