{"id":"W3173194815","doi":"10.1101/2021.06.25.449964","title":"The Mixed Blessing of AMPK Signaling in Cancer Treatments","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Metabolism, Diabetes, and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"AMPK; mTORC1; mTORC2; PI3K/AKT/mTOR pathway; Cancer cell; Regulator; Cell biology; Mechanistic target of rapamycin; Protein kinase A; Signal transduction; AMP-activated protein kinase; Cell growth; Cancer research; Carcinogenesis; Biology; Kinase; Cancer; Chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000221801,0.0002594208,0.0004107933,0.0001598837,0.0002290939,0.0006737826,0.0003361891,0.0008065373,0.003521817],"category_scores_gemma":[0.000735738,0.0001518492,0.0004517561,0.0001887168,0.0004301257,0.0005832913,0.0004719819,0.000543458,0.0003079438],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004641144,"about_ca_system_score_gemma":0.0006368855,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001905862,"about_ca_topic_score_gemma":0.001418677,"domain_scores_codex":[0.9999071,0.00004021779,0.000002935352,0.00001364542,0.0000239068,0.00001200765],"domain_scores_gemma":[0.9998801,0.00005814104,0.00001524615,0.00001403085,0.00001588104,0.00001658566],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0001265955,0.00004832398,0.000799849,0.0001492936,0.00004512566,0.0001155968,0.00003038297,0.9304172,0.004180368,0.04620518,0.003310283,0.01457183],"study_design_scores_gemma":[0.00007222038,0.00008702547,0.0003848416,0.00004156893,0.00002778431,0.00005575093,0.00003544447,0.9406702,0.002628578,0.04653845,0.009442604,0.00001548853],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.4339543,0.01332121,0.418686,0.02124326,0.001800031,0.0001650373,0.0016376,0.0008260626,0.1083665],"genre_scores_gemma":[0.9668051,0.001939452,0.02288472,0.0005648584,0.00008190235,0.00009966436,0.0002002605,0.00008855265,0.007335429],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.003521817,"threshold_uncertainty_score":0.01178169,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01447097746489231,"score_gpt":0.2439036335169638,"score_spread":0.2294326560520715,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}