{"id":"W3173220324","doi":"10.1186/s12974-021-02123-0","title":"Beyond the lesion site: minocycline augments inflammation and anxiety-like behavior following SCI in rats through action on the gut microbiota","year":2021,"lang":"en","type":"article","venue":"Journal of Neuroinflammation","topic":"Spinal Cord Injury Research","field":"Medicine","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"Women and Children’s Health Research Institute; University of Alberta","funders":"Craig H. Neilsen Foundation","keywords":"Minocycline; Medicine; Spinal cord injury; Spinal cord; Lesion; Dysbiosis; Neuroprotection; Immune system; Gut flora; Inflammation; Anesthesia; Immunology; Antibiotics; Pharmacology; Pathology; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009657867,0.0001536273,0.0002375518,0.0001841607,0.0002070566,0.0001198106,0.0001172644,0.00008940886,0.00003556772],"category_scores_gemma":[0.0005209047,0.00009498683,0.0001432308,0.0004540602,0.00004920731,0.0005394126,0.00006798979,0.0006733204,0.00001586341],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001647975,"about_ca_system_score_gemma":0.0001505889,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001022219,"about_ca_topic_score_gemma":0.0000447542,"domain_scores_codex":[0.9979149,0.0003389549,0.0006584301,0.0001924753,0.0006958351,0.0001993908],"domain_scores_gemma":[0.9987342,0.0002242137,0.0004059025,0.0002859071,0.0002887596,0.00006106633],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007637463,0.00007400167,0.005240489,0.00003446521,0.00002251293,0.000211939,0.0002609933,0.0000311063,0.9785747,0.00003589215,0.0005870934,0.0141631],"study_design_scores_gemma":[0.002213188,0.001130169,0.4227151,0.0004257885,0.0002197816,0.001268622,0.0005765077,0.0006908861,0.5675523,0.0002554999,0.002808282,0.0001438619],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9863068,0.0001644437,0.00003732056,0.01230051,0.0004833205,0.0005183087,0.000001680524,0.000008762626,0.0001788484],"genre_scores_gemma":[0.9982973,0.0004862967,0.0003147342,0.0002290505,0.0003745015,0.00001031077,0.00001728335,0.00002100649,0.0002495221],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4174746,"threshold_uncertainty_score":0.3873451,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07659525746479827,"score_gpt":0.3791210264656938,"score_spread":0.3025257690008956,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}