{"id":"W3173280716","doi":"10.1172/jci138022","title":"Serine hydroxymethyltransferase 2 expression promotes tumorigenesis in rhabdomyosarcoma with 12q13-q14 amplification","year":2021,"lang":"zh","type":"article","venue":"Journal of Clinical Investigation","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Pediatric Oncology Group","funders":"Medical School, University of Michigan; National Institutes of Health; George Washington University; National Cancer Institute; Princeton University","keywords":"Amplicon; Biology; Carcinogenesis; Cancer research; Rhabdomyosarcoma; Serine hydroxymethyltransferase; Molecular biology; Gene; Genetics; Serine; Polymerase chain reaction; Pathology; Sarcoma; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001391473,0.0001993262,0.0001983691,0.0003328447,0.0001052595,0.0001807721,0.00007316729,0.0001599165,0.0006804691],"category_scores_gemma":[0.0001399778,0.0001599235,0.0001688359,0.0001521837,0.000185195,0.00009816884,0.000167921,0.0002490978,0.0001521519],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001409336,"about_ca_system_score_gemma":0.0001159735,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000666967,"about_ca_topic_score_gemma":0.0009882447,"domain_scores_codex":[0.9999002,0.00001654941,0.00001017139,0.00001547836,0.00002995669,0.00002766153],"domain_scores_gemma":[0.9998853,0.00002718308,0.00003887796,0.000009383968,0.00001180767,0.00002738397],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.000188841,0.00002065571,0.00504367,0.00001525379,0.000008096448,0.0002018018,0.00002472985,0.00006553106,0.9937158,0.00002076966,0.00001877562,0.0006761401],"study_design_scores_gemma":[0.00003791475,0.001206313,0.2986189,0.000007530457,0.00007284246,0.002462874,0.0001828657,0.002734414,0.6933921,0.00007936922,0.001195915,0.000008881005],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9993788,0.0002002828,0.0001895149,0.00001255532,0.000001712205,0.000003816296,0.00003116447,0.00001460558,0.0001675826],"genre_scores_gemma":[0.9992647,0.0001270376,0.0001989947,0.000007735821,0.000001974882,0.000005196864,0.00008865429,0.000002685289,0.0003029047],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006804691,"threshold_uncertainty_score":0.002276421,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03517303986054794,"score_gpt":0.3311074156628734,"score_spread":0.2959343758023255,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}