{"id":"W3173338425","doi":"10.1016/j.jagp.2021.06.016","title":"Apathy as a Treatment Target in Alzheimer's Disease: Implications for Clinical Trials","year":2021,"lang":"en","type":"review","venue":"American Journal of Geriatric Psychiatry","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":62,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Sunnybrook Health Science Centre; University of Calgary","funders":"National Institute on Aging; National Health and Medical Research Council; Medical Research Council; Canadian Institutes of Health Research; U.S. Department of Veterans Affairs","keywords":"Apathy; Neurocognitive; Intervention (counseling); Dementia; Clinical trial; Psychology; Psychological intervention; Disease; Psychiatry; Medicine; Psychotherapist; Clinical psychology; Cognition; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.004568263,0.0005225681,0.00602688,0.0009264367,0.00007962116,0.00006136784,0.0003335438,0.000167579,0.0002171272],"category_scores_gemma":[0.001452255,0.0003611193,0.004566686,0.001396095,0.0001839205,0.00007708352,0.00005394341,0.000634668,0.00002450225],"about_ca_system_candidate":true,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002526303,"about_ca_system_score_gemma":0.01067596,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001378951,"about_ca_topic_score_gemma":0.000001797335,"domain_scores_codex":[0.9925703,0.001897013,0.00395839,0.000580551,0.0004477784,0.0005459404],"domain_scores_gemma":[0.9927256,0.001824378,0.003489884,0.0005639273,0.0004809712,0.0009152797],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0006237103,0.002290089,0.01988133,0.0007456829,0.003251396,0.0000764599,0.00001328489,1.065293e-7,7.300908e-8,0.00009834628,0.005327269,0.9676923],"study_design_scores_gemma":[0.004220421,0.006412692,0.01074335,0.00450926,0.01772201,0.0005029119,0.0001876613,8.473953e-7,1.079329e-7,0.0003935798,0.9549656,0.00034155],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003517545,0.9920298,0.000306782,0.002863346,0.001305586,0.002675683,0.0002179963,0.00001253172,0.0002364811],"genre_scores_gemma":[0.0001465626,0.9900683,0.005526647,0.0003086571,0.003033629,0.0004703682,0.0002178964,0.0000840272,0.0001439793],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9673507,"threshold_uncertainty_score":0.9998841,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1776459100774338,"score_gpt":0.5423888673636663,"score_spread":0.3647429572862325,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}