{"id":"W3173362811","doi":"10.1016/j.celrep.2021.109291","title":"Targeting p130Cas- and microtubule-dependent MYC regulation sensitizes pancreatic cancer to ERK MAPK inhibition","year":2021,"lang":"en","type":"article","venue":"Cell Reports","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute of General Medical Sciences; National Cancer Institute; University of North Carolina; Merck; Deutsche Forschungsgemeinschaft; American Association for Cancer Research; Eli Lilly and Company; American Cancer Society; Doris Duke Charitable Foundation; Pancreatic Cancer Action Network; Lustgarten Foundation; U.S. Department of Defense","keywords":"Pancreatic cancer; KRAS; Synthetic lethality; MAPK/ERK pathway; Cancer research; Biology; Small interfering RNA; Cancer cell; Cell biology; Kinase; Cancer; Mutant; Transfection; Cell culture; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008134026,0.0003081811,0.0001887813,0.0001717231,0.0001303655,0.0002646776,0.0001684061,0.0001760063,0.001216707],"category_scores_gemma":[0.00006440996,0.0001107456,0.0001914939,0.0001151668,0.0001397959,0.0001425741,0.0001415974,0.0005780209,0.0002930826],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002544985,"about_ca_system_score_gemma":0.0001969368,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003316259,"about_ca_topic_score_gemma":0.001145171,"domain_scores_codex":[0.9999089,0.00001057402,0.00000891503,0.00001851673,0.00003334983,0.00001966227],"domain_scores_gemma":[0.9999597,0.000006886218,0.00001230766,0.000005735188,0.000004648547,0.00001076877],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004424688,0.00003199115,0.0001579768,0.0000181487,0.000003306953,0.00002693298,0.000004592047,0.00009039527,0.9983237,0.00007468275,0.00004483964,0.001179042],"study_design_scores_gemma":[0.000007552469,0.0001184428,0.001411163,0.000001538246,0.000006611775,0.0001575106,0.000007524646,0.0005915153,0.9964057,0.00002433233,0.001266436,0.00000152493],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9920169,0.0008101845,0.002880383,0.0001647556,0.000028608,0.00003666526,0.0003931205,0.000139682,0.003529718],"genre_scores_gemma":[0.994118,0.0006916588,0.002350688,0.00004195997,0.000005214709,0.00003317493,0.0003413057,0.00001975553,0.002398216],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001216707,"threshold_uncertainty_score":0.004070282,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006662341930106495,"score_gpt":0.2155697738878019,"score_spread":0.2089074319576953,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}