{"id":"W3173388073","doi":"10.1101/2021.06.27.449656","title":"DUSP6 mediates resistance to JAK2 inhibition and drives leukemic progression","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre","funders":"National Cancer Institute; National Institutes of Health; Alvin J. Siteman Cancer Center; Edward P. Evans Foundation; McGill University; Canadian Institutes of Health Research; Leukemia and Lymphoma Society","keywords":"Cancer research; Myeloid leukemia; Transcriptome; Biology; Progenitor cell; Myeloid; Gene expression profiling; Cell growth; Cell biology; Stem cell; Gene expression; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000134329,0.0002510565,0.0001894381,0.0001541521,0.0001473685,0.000352949,0.000152185,0.000186672,0.001449349],"category_scores_gemma":[0.00008574141,0.00009558202,0.000122773,0.0001137105,0.0001874655,0.0001176436,0.0002139675,0.0006281308,0.0004165362],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000310678,"about_ca_system_score_gemma":0.0001575249,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003481924,"about_ca_topic_score_gemma":0.0005354224,"domain_scores_codex":[0.9998738,0.00002105445,0.000009658864,0.00003043997,0.0000345488,0.00003052576],"domain_scores_gemma":[0.9999468,0.000004976238,0.00001619788,0.000006727112,0.00000594647,0.00001929955],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001813068,0.00004240378,0.0008469853,0.00003349866,0.000007543932,0.00007198111,0.00001191463,0.000180533,0.9944428,0.0002368856,0.0002111045,0.003733134],"study_design_scores_gemma":[0.00004658939,0.0004583409,0.01096205,0.00001073793,0.00001535195,0.0006850685,0.00005259861,0.004072951,0.9754429,0.0002434555,0.00800533,0.000004549884],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927925,0.001976254,0.002234062,0.0001844788,0.00002868227,0.00002530702,0.0006546558,0.000136515,0.001967741],"genre_scores_gemma":[0.9968477,0.0005707025,0.0006336499,0.00003871973,0.000007791444,0.00001422066,0.0004798305,0.000009165989,0.001398177],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001449349,"threshold_uncertainty_score":0.00484854,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01370592534285674,"score_gpt":0.2644002446326502,"score_spread":0.2506943192897934,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}