{"id":"W3173415313","doi":"10.15698/mic2021.07.755","title":"LasR-regulated proteases in acute vs. chronic lung infection: a double-edged sword","year":2021,"lang":"en","type":"letter","venue":"Microbial Cell","topic":"Bacterial biofilms and quorum sensing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre","funders":"Canadian Institutes of Health Research; Deutscher Akademischer Austauschdienst; Cystic Fibrosis Canada","keywords":"Proteases; Cystic fibrosis; Biology; Pseudomonas aeruginosa; Inflammation; Microbiology; Immunology; Pathogen; Virulence; Respiratory epithelium; Chronic infection; Lung; Immunity; Immune system; Epithelium; Medicine; Gene; Bacteria; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002009928,0.0005068069,0.001039007,0.001113336,0.000339256,0.001551234,0.0007271546,0.002164284,0.001422493],"category_scores_gemma":[0.001512061,0.0002663511,0.0005191616,0.0005545989,0.001961942,0.002362783,0.001589255,0.002249843,0.0007296928],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003775533,"about_ca_system_score_gemma":0.0004019664,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002846289,"about_ca_topic_score_gemma":0.0003226767,"domain_scores_codex":[0.9991216,0.0002088826,0.0001316396,0.0002311333,0.000179201,0.0001274912],"domain_scores_gemma":[0.99834,0.0004408302,0.0002730243,0.0001625294,0.0003957706,0.0003878877],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.009167684,0.0008205865,0.05238368,0.007649835,0.000811592,0.01021204,0.002582554,0.0005626142,0.224924,0.02002184,0.05583604,0.6150275],"study_design_scores_gemma":[0.0009934355,0.007189344,0.4362499,0.006321562,0.001082306,0.06531631,0.006627705,0.005443796,0.04571394,0.0460592,0.3784437,0.000558803],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"commentary","genre_scores_codex":[0.1768828,0.7658315,0.005818927,0.0385607,0.004613674,0.00005115665,0.0003170567,0.0002314117,0.007692776],"genre_scores_gemma":[0.6649092,0.2815939,0.00268628,0.02277995,0.01620474,0.00007163252,0.0003777615,0.000129238,0.01124734],"genre_candidate":"commentary","genre_consensus":null,"teacher_disagreement_score":0.002164284,"threshold_uncertainty_score":0.01062965,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007366600248237456,"score_gpt":0.2158754040279058,"score_spread":0.2085088037796684,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}