{"id":"W3173426600","doi":"10.1096/fasebj.2018.32.1_supplement.527.1","title":"CONFORMATIONAL FLUCTUATIONS RELATED TO CATALYSIS IN HUMAN RIBONUCLEASE SUPERFAMILY","year":2018,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"Protein Structure and Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institut National de la Recherche Scientifique","funders":"","keywords":"RNase P; Ribonuclease; Molecular dynamics; Chemistry; Protein dynamics; Catalytic cycle; Conformational change; Conformational ensembles; Protein structure; RNase H; Function (biology); Enzyme; Biophysics; Stereochemistry; Computational chemistry; Biology; Biochemistry; RNA; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001792068,0.0001028561,0.0001418188,0.0002957348,0.0001459587,0.0002535893,0.00009599535,0.0001785597,0.0006042389],"category_scores_gemma":[0.0007296221,0.0001009504,0.0001175734,0.0003589374,0.0002484937,0.0001732495,0.0001219419,0.0002111698,0.000118207],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002260386,"about_ca_system_score_gemma":0.00008316444,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004180974,"about_ca_topic_score_gemma":0.0002932529,"domain_scores_codex":[0.9999022,0.0000188364,0.000005947691,0.00002932838,0.00003152429,0.00001216232],"domain_scores_gemma":[0.9998279,0.0000573647,0.00006810499,0.00001498058,0.00001493468,0.00001676376],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001012285,0.0001500074,0.05488602,0.000244983,0.0001315846,0.0007745125,0.0005499034,0.03330962,0.8267995,0.006057248,0.002138384,0.07394595],"study_design_scores_gemma":[0.00006112801,0.0007377719,0.5541803,0.00004755545,0.0001807122,0.002417923,0.0002875199,0.1936439,0.2175532,0.02203102,0.008687016,0.0001718852],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9900563,0.001779948,0.006119803,0.000143784,0.00002384806,0.00001009977,0.0001879986,0.0001182235,0.001560024],"genre_scores_gemma":[0.9983398,0.0003690105,0.0006851003,0.00003867866,0.00002265755,0.000008191151,0.0001853551,0.00001353288,0.0003377723],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006042389,"threshold_uncertainty_score":0.002021372,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006597818615345799,"score_gpt":0.2502152760699849,"score_spread":0.2436174574546391,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}