{"id":"W3173438664","doi":"10.1371/journal.pone.0253475","title":"Iron overload inhibits BMP/SMAD and IL-6/STAT3 signaling to hepcidin in cultured hepatocytes","year":2021,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Iron Metabolism and Disorders","field":"Medicine","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"Institute of Nutrition, Metabolism and Diabetes; Fonds de Recherche du Québec - Santé; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Hepcidin; SMAD; BMPR2; Cell biology; Signal transduction; Smad2 Protein; Bone morphogenetic protein 2; Chemistry; STAT3; Bone morphogenetic protein; Internal medicine; Endocrinology; Biology; Medicine; Biochemistry; Inflammation; Gene; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001661943,0.0002818851,0.0002931542,0.0002085561,0.0001382261,0.0002445434,0.000145119,0.0001947084,0.001699852],"category_scores_gemma":[0.00008607449,0.0001556171,0.0003125032,0.0001076441,0.0002136774,0.0001524353,0.0001747868,0.0005409139,0.0004394597],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000195404,"about_ca_system_score_gemma":0.0002806853,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001021882,"about_ca_topic_score_gemma":0.001770305,"domain_scores_codex":[0.9998709,0.0000256971,0.00001508411,0.00002019847,0.00003033327,0.00003777129],"domain_scores_gemma":[0.9999306,0.00001708866,0.00001243328,0.00001094833,0.000009354102,0.00001959879],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002868795,0.00004600472,0.0001013936,0.00003957912,0.00000369484,0.00003696015,0.00001588465,0.00004276015,0.9985784,0.00004645308,0.00004923062,0.0007526599],"study_design_scores_gemma":[0.00003598661,0.0004230386,0.003099761,0.000005341312,0.00001334225,0.00008983687,0.00004040574,0.001027419,0.9936576,0.00003422075,0.001569038,0.000003822561],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934222,0.001299515,0.002129595,0.0001453454,0.00006551657,0.00003510155,0.0003843043,0.00008972406,0.002428704],"genre_scores_gemma":[0.9932373,0.0007778381,0.001522951,0.0001075077,0.00001930873,0.00004924417,0.0005435029,0.00001998687,0.003722408],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001699852,"threshold_uncertainty_score":0.005686641,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03219590419056701,"score_gpt":0.2452754237365037,"score_spread":0.2130795195459367,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}