{"id":"W3173438664","doi":"10.1371/journal.pone.0253475","title":"Iron overload inhibits BMP/SMAD and IL-6/STAT3 signaling to hepcidin in cultured hepatocytes","year":2021,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Iron Metabolism and Disorders","field":"Medicine","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"Institute of Nutrition, Metabolism and Diabetes; Fonds de Recherche du Québec - Santé; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Hepcidin; SMAD; BMPR2; Cell biology; Signal transduction; Smad2 Protein; Bone morphogenetic protein 2; Chemistry; STAT3; Bone morphogenetic protein; Internal medicine; Endocrinology; Biology; Medicine; Biochemistry; Inflammation; Gene; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001258739,0.0001572487,0.0003885908,0.00009784489,0.00004628093,0.00002886236,0.00004235821,0.00009025595,0.0001848473],"category_scores_gemma":[0.0003368516,0.0001484822,0.00003788911,0.0002845787,0.0000299816,0.00008791158,0.00006738435,0.0001755432,0.0000713302],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003300555,"about_ca_system_score_gemma":0.00007721582,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001074438,"about_ca_topic_score_gemma":0.0001397919,"domain_scores_codex":[0.9987527,0.00005008241,0.0002408249,0.0003362343,0.0003287303,0.0002914019],"domain_scores_gemma":[0.9994312,0.00004341701,0.00003595614,0.0002052503,0.00008829369,0.0001959057],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002414539,0.001374849,0.05718669,0.0005541468,0.00003868508,0.0001344406,0.00293022,0.000008669827,0.93499,0.000269999,0.0005950893,0.001675726],"study_design_scores_gemma":[0.0038804,0.0001916164,0.02358365,0.0007522673,0.0002419497,0.00001298857,0.001778467,0.00009302912,0.9677961,0.0002140658,0.001118548,0.0003369144],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9920242,0.004321954,0.00002022139,0.001591134,0.00003348277,0.000369902,0.00001841161,0.00004591875,0.001574735],"genre_scores_gemma":[0.9897702,0.00057096,0.005872465,0.001794697,0.0001276761,0.00003243309,0.0000502267,0.00002636043,0.001754961],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03360304,"threshold_uncertainty_score":0.6054928,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03219590419056701,"score_gpt":0.2452754237365037,"score_spread":0.2130795195459367,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}