{"id":"W3173448041","doi":"10.3390/antiox10060981","title":"Sigma 1 Receptor Co-Localizes with NRF2 in Retinal Photoreceptor Cells","year":2021,"lang":"en","type":"article","venue":"Antioxidants","topic":"Pharmacological Receptor Mechanisms and Effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Eye Institute; Foundation Fighting Blindness","keywords":"Retinal; Molecular biology; Proximity ligation assay; Biotinylation; Antibody; Polyclonal antibodies; Cell biology; Receptor; Immunoprecipitation; Biology; Monoclonal antibody; Agarose; Chemistry; Biochemistry; Immunology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002032438,0.0002069434,0.0002257921,0.0000355648,0.00006335699,0.00003060852,0.0001610839,0.0001779934,0.0009906144],"category_scores_gemma":[0.00007080629,0.0001718553,0.00007798101,0.0001859891,0.00007503854,0.000006717262,0.00007552806,0.000151937,0.0001025795],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002179922,"about_ca_system_score_gemma":0.0001121965,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001436458,"about_ca_topic_score_gemma":0.00003191568,"domain_scores_codex":[0.9985455,0.0001488664,0.0001989796,0.0005083483,0.0001945617,0.0004037762],"domain_scores_gemma":[0.9994489,0.00002802242,0.00006734507,0.0002279641,0.00008469912,0.0001430867],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002783299,0.0001833673,0.002083672,0.00002454587,0.00003034903,0.00006264513,0.00001944321,0.00001623641,0.9885897,0.0000343116,0.007414183,0.001263189],"study_design_scores_gemma":[0.001033426,0.0004526315,0.001510598,0.00005408821,0.000009897574,0.00001622015,0.00006277164,0.00002600512,0.9438885,0.00002227682,0.05267088,0.0002526902],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966434,0.0003752126,0.0005493826,0.00008471309,0.0003079871,0.0001851664,0.0000337036,0.00002065352,0.001799735],"genre_scores_gemma":[0.9956227,0.000685047,0.001573242,0.0006948425,0.00019043,0.00003508604,0.0001192729,0.00002888011,0.00105051],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04525669,"threshold_uncertainty_score":0.9999226,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008582710204049987,"score_gpt":0.26277503701595,"score_spread":0.2541923268119,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}