{"id":"W3173448041","doi":"10.3390/antiox10060981","title":"Sigma 1 Receptor Co-Localizes with NRF2 in Retinal Photoreceptor Cells","year":2021,"lang":"en","type":"article","venue":"Antioxidants","topic":"Pharmacological Receptor Mechanisms and Effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Eye Institute; Foundation Fighting Blindness","keywords":"Retinal; Molecular biology; Proximity ligation assay; Biotinylation; Antibody; Polyclonal antibodies; Cell biology; Receptor; Immunoprecipitation; Biology; Monoclonal antibody; Agarose; Chemistry; Biochemistry; Immunology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001727298,0.0003077783,0.0003616552,0.0003601313,0.0003278314,0.0004002116,0.0001738166,0.0003793092,0.001513941],"category_scores_gemma":[0.0001207568,0.0002747104,0.0004428107,0.000249089,0.0001955977,0.0002758169,0.0003382479,0.0004518789,0.001144261],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003093295,"about_ca_system_score_gemma":0.0002346713,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009930204,"about_ca_topic_score_gemma":0.00150215,"domain_scores_codex":[0.9997336,0.00002816894,0.00002316049,0.00009627509,0.00006792241,0.00005084243],"domain_scores_gemma":[0.9998622,0.00001147642,0.00003987491,0.00001965378,0.00003219323,0.00003460331],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005005654,0.000007863265,0.0004923344,0.00003741903,0.000005400324,0.0001304771,0.0000299701,0.000009851276,0.9988607,0.00005630332,0.00003329219,0.000286387],"study_design_scores_gemma":[0.00003512273,0.0003173173,0.09362229,0.00004159638,0.00005062528,0.002651981,0.0004501819,0.002083877,0.8943623,0.0001874502,0.006170334,0.0000269516],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9884849,0.003986706,0.004678418,0.0002442644,0.00004372091,0.00001794251,0.0005467971,0.00009447059,0.001902833],"genre_scores_gemma":[0.9895918,0.001214696,0.002738142,0.000116107,0.00002330722,0.00003816271,0.0009441484,0.00002914896,0.005304457],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001513941,"threshold_uncertainty_score":0.005064607,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008582710204049987,"score_gpt":0.26277503701595,"score_spread":0.2541923268119,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}