{"id":"W3173461290","doi":"10.1073/pnas.2025930118","title":"Antitumor efficacy and reduced toxicity using an anti-CD137 Probody therapeutic","year":2021,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Bristol-Myers Squibb Canada; Ministerio de Ciencia e Innovación","keywords":"CD137; Agonist; Pharmacology; Cancer research; Chemistry; Cytotoxic T cell; Antibody; Monoclonal antibody; Prodrug; Proteases; Immunotherapy; Medicine; Immunology; Receptor; Immune system; In vitro; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001735738,0.0004187855,0.0003475746,0.0002316869,0.0000936444,0.0003878335,0.0002351786,0.0003257633,0.001212243],"category_scores_gemma":[0.0001248255,0.00009709096,0.0001752641,0.0001278485,0.0002193379,0.0002862705,0.0001817841,0.0008659381,0.0002237039],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003110159,"about_ca_system_score_gemma":0.000355741,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002616619,"about_ca_topic_score_gemma":0.0004453449,"domain_scores_codex":[0.9998504,0.00002538614,0.00000978971,0.00002993158,0.00003768927,0.00004686588],"domain_scores_gemma":[0.9999481,0.00000946132,0.00001302948,0.000008192026,0.000006152254,0.00001495863],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004495291,0.0003316142,0.0001445905,0.00007138477,0.0000115899,0.00006368438,0.00002031788,0.000493428,0.9872618,0.0005708922,0.0001263835,0.01045479],"study_design_scores_gemma":[0.0001986933,0.004149403,0.0008579874,0.000006959411,0.00004353787,0.0004276572,0.00001011146,0.001755789,0.9894269,0.00009916958,0.003019037,0.000004841007],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9896715,0.001574854,0.005354793,0.0001504479,0.00004011253,0.00008339806,0.0001608279,0.0001263707,0.002837733],"genre_scores_gemma":[0.9947389,0.0005441112,0.0028599,0.00005176755,0.00001346072,0.00004744074,0.0002067531,0.00001286688,0.001524778],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001212243,"threshold_uncertainty_score":0.004055321,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1341946312290324,"score_gpt":0.4037151791293229,"score_spread":0.2695205479002906,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}