{"id":"W3173461290","doi":"10.1073/pnas.2025930118","title":"Antitumor efficacy and reduced toxicity using an anti-CD137 Probody therapeutic","year":2021,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Bristol-Myers Squibb Canada; Ministerio de Ciencia e Innovación","keywords":"CD137; Agonist; Pharmacology; Cancer research; Chemistry; Cytotoxic T cell; Antibody; Monoclonal antibody; Prodrug; Proteases; Immunotherapy; Medicine; Immunology; Receptor; Immune system; In vitro; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001252354,0.00008953651,0.0002156526,0.0001473827,0.0001923743,0.0000383224,0.0002965208,0.00006821554,0.0000866388],"category_scores_gemma":[0.0004053758,0.00006037372,0.00005458838,0.0008619366,0.0008843721,0.0003206221,0.0001222049,0.0002120297,3.877124e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003853465,"about_ca_system_score_gemma":0.000149604,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005124565,"about_ca_topic_score_gemma":4.020335e-8,"domain_scores_codex":[0.9980346,0.00001375982,0.0002483775,0.0003000267,0.001222461,0.0001807878],"domain_scores_gemma":[0.9992051,0.00008322288,0.0001767785,0.00001422271,0.0004537692,0.00006694588],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004058684,0.0001682209,0.00600362,0.00008448028,0.00002502066,5.722203e-8,0.0001680193,0.00001594153,0.9893448,0.003091299,0.00001908668,0.001038866],"study_design_scores_gemma":[0.0004649089,0.0001054681,0.1523885,0.0001300753,0.00002357129,0.0001071951,0.0001830954,0.001928287,0.8411169,0.003413574,0.00007703087,0.00006140164],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941173,0.0002852289,7.628237e-7,0.003208682,0.00001345914,0.0002716408,0.000003395805,0.0000108335,0.002088656],"genre_scores_gemma":[0.997772,0.00007055734,0.001419752,0.0003289211,0.00009827402,0.000002634231,1.686579e-7,0.000006358467,0.000301268],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1482279,"threshold_uncertainty_score":0.3258506,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1341946312290324,"score_gpt":0.4037151791293229,"score_spread":0.2695205479002906,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}