{"id":"W3173474932","doi":"10.1002/art.41911","title":"Safety and Efficacy of Upadacitinib in Patients With Active Ankylosing Spondylitis and an Inadequate Response to Nonsteroidal Antiinflammatory Drug Therapy: One‐Year Results of a Double‐Blind, Placebo‐Controlled Study and Open‐Label Extension","year":2021,"lang":"en","type":"article","venue":"Arthritis & Rheumatology","topic":"Spondyloarthritis Studies and Treatments","field":"Medicine","cited_by":64,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"AbbVie","keywords":"Ankylosing spondylitis; Medicine; Placebo; Nonsteroidal; Spondylitis; Drug; Open label; Clinical trial; Internal medicine; Pharmacology; Alternative medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00317133,0.0006566591,0.001961314,0.0003660015,0.0003416942,0.0007754187,0.0004791234,0.000948563,0.001323861],"category_scores_gemma":[0.002099174,0.0004050493,0.001189031,0.0004250033,0.0007123078,0.0007253848,0.0002647175,0.001382637,0.0002356839],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006432355,"about_ca_system_score_gemma":0.0009138776,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006165436,"about_ca_topic_score_gemma":0.001378421,"domain_scores_codex":[0.9990024,0.0004715371,0.0001108149,0.000150482,0.0001622752,0.0001024081],"domain_scores_gemma":[0.9976434,0.0005318384,0.0009858534,0.0001772068,0.0002399621,0.0004217752],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8870712,0.01151907,0.02552712,0.001066083,0.002768665,0.0001950087,0.0002100347,0.0006392091,0.01008552,0.00005289765,0.0008368302,0.06002837],"study_design_scores_gemma":[0.4824879,0.4007059,0.1073902,0.0001010871,0.002768305,0.0005023674,0.0001179489,0.0009400853,0.00339076,0.00007441312,0.001464368,0.00005678647],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958555,0.002998105,0.0001223663,0.0000868241,0.00003618542,0.0002790384,0.0003207286,0.00001389889,0.0002873305],"genre_scores_gemma":[0.9980526,0.000805782,0.0002173798,0.0001308005,0.00007086402,0.000144574,0.0003804058,0.000003128478,0.0001944918],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00317133,"threshold_uncertainty_score":0.01677179,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02281065462069521,"score_gpt":0.295997446713378,"score_spread":0.2731867920926828,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}