{"id":"W3173474932","doi":"10.1002/art.41911","title":"Safety and Efficacy of Upadacitinib in Patients With Active Ankylosing Spondylitis and an Inadequate Response to Nonsteroidal Antiinflammatory Drug Therapy: One‐Year Results of a Double‐Blind, Placebo‐Controlled Study and Open‐Label Extension","year":2021,"lang":"en","type":"article","venue":"Arthritis & Rheumatology","topic":"Spondyloarthritis Studies and Treatments","field":"Medicine","cited_by":64,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"AbbVie","keywords":"Ankylosing spondylitis; Medicine; Placebo; Nonsteroidal; Spondylitis; Drug; Open label; Clinical trial; Internal medicine; Pharmacology; Alternative medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006958419,0.0002952706,0.00159765,0.0002834103,0.0001607025,0.00003495936,0.00007684646,0.0001001119,0.00001520841],"category_scores_gemma":[0.0003299284,0.0002618108,0.00002969035,0.0002865732,0.0003134287,0.000242409,0.0002721395,0.0001734278,8.632383e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000292611,"about_ca_system_score_gemma":0.0001475823,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005553755,"about_ca_topic_score_gemma":0.00201213,"domain_scores_codex":[0.997176,0.0005974686,0.0008687958,0.0007354795,0.0002665743,0.0003556845],"domain_scores_gemma":[0.9981447,0.0006311543,0.0003036354,0.0004023616,0.0003174629,0.0002006952],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.6968432,0.002612642,0.2445348,0.00003296372,0.0003639123,0.000322614,0.008175264,5.907908e-7,0.0004415358,0.00005515778,0.000003792619,0.04661355],"study_design_scores_gemma":[0.4483556,0.005706123,0.5412234,0.0009400049,0.00005629321,0.0001263513,0.00279908,0.000006262663,0.0005595704,0.00001113577,0.00004844806,0.0001677456],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938618,0.002200327,0.000001679626,0.0003570699,0.0000471508,0.00323817,0.0002070633,0.00001525836,0.00007147599],"genre_scores_gemma":[0.9972468,0.001908027,0.0005970969,0.00004677122,0.000004554219,0.00006928616,0.00007222103,0.00003281629,0.00002240979],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2966887,"threshold_uncertainty_score":0.9999834,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02281065462069521,"score_gpt":0.295997446713378,"score_spread":0.2731867920926828,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}