{"id":"W3173479195","doi":"10.1101/2021.07.02.450896","title":"Implications of Spike-glycoprotein processing at S1/S2 by Furin, at S2’ by Furin and/or TMPRSS2 and shedding of ACE2: cell-to-cell fusion, cell entry and infectivity of SARS-CoV-2","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":4,"is_retracted":true,"has_abstract":true,"ca_institutions":"Montreal Clinical Research Institute","funders":"","keywords":"Furin; Infectivity; Glycoprotein; Virology; Cell fusion; Disclaimer; Cell; Biology; Lipid bilayer fusion; Coronavirus disease 2019 (COVID-19); Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Computational biology; Cell biology; Molecular biology; Biochemistry; Medicine; Virus; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":{"nature":"Retraction","reason":"Duplication of/in Article;","date":"7/15/2021 0:00","openalex_flagged":true},"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002749979,0.0003387134,0.0002345103,0.0002323377,0.0003479596,0.0008780877,0.0001853439,0.0006628089,0.005719268],"category_scores_gemma":[0.0004371252,0.0001395927,0.0002654,0.0001522156,0.0004144196,0.0005269733,0.0002247603,0.0005233787,0.001204028],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006891346,"about_ca_system_score_gemma":0.0005156285,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001458507,"about_ca_topic_score_gemma":0.0011488,"domain_scores_codex":[0.9999053,0.00002242965,0.000005202071,0.00001428369,0.00002501482,0.00002760104],"domain_scores_gemma":[0.9998953,0.0000371893,0.0000185129,0.000008070641,0.00001263451,0.00002830238],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004497924,0.0002640472,0.006691362,0.0003801577,0.00006525588,0.003584369,0.0002942055,0.002517328,0.9298362,0.02076414,0.009373871,0.02173129],"study_design_scores_gemma":[0.0003600921,0.0008859563,0.1305688,0.0001421895,0.0001412595,0.007560005,0.001557125,0.02832655,0.7491633,0.03868281,0.04251978,0.00009219039],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9620587,0.009817058,0.002323557,0.005894815,0.0005169451,0.00002889207,0.00100639,0.00006718083,0.01828668],"genre_scores_gemma":[0.9827779,0.003530563,0.001047501,0.0002453377,0.0001231594,0.00001307914,0.001180828,0.00002867117,0.01105304],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005719268,"threshold_uncertainty_score":0.01913285,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01987087267608775,"score_gpt":0.2831215179541084,"score_spread":0.2632506452780207,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}