{"id":"W3173510214","doi":"10.1158/1078-0432.ccr-20-4027","title":"Combined EZH2 Inhibition and IKAROS Degradation Leads to Enhanced Antitumor Activity in Diffuse Large B-cell Lymphoma","year":2021,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"Spinal Cord Injury BC; Vector Institute; Princess Margaret Cancer Centre; BC Cancer Agency; University of Toronto; University Health Network","funders":"Canadian Institutes of Health Research; Terry Fox Research Institute; Canadian Hematology Society; BC Cancer Foundation; Natural Sciences and Engineering Research Council of Canada; Princess Margaret Cancer Foundation; Leukemia and Lymphoma Society of Canada","keywords":"Lenalidomide; Cancer research; Vorinostat; EZH2; Medicine; Diffuse large B-cell lymphoma; Panobinostat; Epigenetics; Biology; Lymphoma; Immunology; Histone deacetylase; Multiple myeloma; Histone; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001318656,0.0002378771,0.000333071,0.0001726433,0.00008030052,0.0002756957,0.0001230638,0.0001572216,0.001140396],"category_scores_gemma":[0.00007788269,0.0001020007,0.000187875,0.0001221511,0.0001464237,0.0001100457,0.0001329756,0.0004102249,0.0003021403],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00026302,"about_ca_system_score_gemma":0.0001466887,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003347704,"about_ca_topic_score_gemma":0.0009735655,"domain_scores_codex":[0.9998779,0.00001336901,0.0000109911,0.0000302382,0.00003966012,0.00002774263],"domain_scores_gemma":[0.9999595,0.000005980852,0.00001140148,0.000005297862,0.000004162561,0.00001363098],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001766568,0.00004189781,0.0003923678,0.00004310207,0.00001245495,0.00003255883,0.000005357552,0.0001411862,0.9965837,0.00002404124,0.00007006493,0.002476539],"study_design_scores_gemma":[0.00007111383,0.0007110332,0.006507067,0.000004639089,0.00004211254,0.0002808026,0.00002612631,0.001165724,0.9885909,0.0000271836,0.002568997,0.000004381654],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995097,0.001616652,0.001408815,0.00008765658,0.00001934881,0.00002614708,0.0004822703,0.0001769236,0.001085181],"genre_scores_gemma":[0.9972709,0.0004737596,0.0007333576,0.00005102423,0.000004272304,0.00002039735,0.0004178619,0.00001382079,0.001014538],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001140396,"threshold_uncertainty_score":0.003814995,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08207514444780283,"score_gpt":0.4472204411841452,"score_spread":0.3651452967363424,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}