{"id":"W3173510214","doi":"10.1158/1078-0432.ccr-20-4027","title":"Combined EZH2 Inhibition and IKAROS Degradation Leads to Enhanced Antitumor Activity in Diffuse Large B-cell Lymphoma","year":2021,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"Spinal Cord Injury BC; Vector Institute; Princess Margaret Cancer Centre; BC Cancer Agency; University of Toronto; University Health Network","funders":"Canadian Institutes of Health Research; Terry Fox Research Institute; Canadian Hematology Society; BC Cancer Foundation; Natural Sciences and Engineering Research Council of Canada; Princess Margaret Cancer Foundation; Leukemia and Lymphoma Society of Canada","keywords":"Lenalidomide; Cancer research; Vorinostat; EZH2; Medicine; Diffuse large B-cell lymphoma; Panobinostat; Epigenetics; Biology; Lymphoma; Immunology; Histone deacetylase; Multiple myeloma; Histone; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001139869,0.00009647424,0.0001749908,0.0000702157,0.00009684025,0.00004868503,0.00007917698,0.0001826896,0.00001926051],"category_scores_gemma":[0.00069487,0.0001000843,0.00005065553,0.0003034276,0.00008543349,0.000007728262,0.0002355584,0.0001903841,0.00001089506],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004692243,"about_ca_system_score_gemma":0.0002680827,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008455077,"about_ca_topic_score_gemma":0.001154219,"domain_scores_codex":[0.9981444,0.0004739522,0.0002808424,0.0005196663,0.0002544305,0.0003266981],"domain_scores_gemma":[0.9990994,0.0001245071,0.00004789873,0.0002930507,0.000277191,0.0001579721],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003337983,0.001306821,0.02145797,0.00002878677,0.000006089171,0.000007887983,0.0000278885,0.000005023084,0.9613115,0.00003044746,0.0001869197,0.0152969],"study_design_scores_gemma":[0.004558912,0.0004056838,0.1096234,0.00002661198,0.00000370892,1.954855e-7,0.00002616765,0.00007106617,0.8830305,0.000124628,0.002013586,0.0001156032],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967963,0.0008454615,0.001021177,0.0005872,0.0001257632,0.0002651466,0.00002611269,0.000005518007,0.0003273045],"genre_scores_gemma":[0.9956003,0.002921315,0.0001789004,0.0001445549,0.0001953017,0.0000732247,0.00008508616,0.00001672482,0.0007845662],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08816537,"threshold_uncertainty_score":0.4081319,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08207514444780283,"score_gpt":0.4472204411841452,"score_spread":0.3651452967363424,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}